The transgenic LmnaG609G progeric mouse represents an outstanding animal model for studying the human Hutchinson-Gilford Progeria Syndrome (HGPS) caused by a mutation in the LMNA gene, coding for the nuclear envelope protein Lamin A/C, and, as an important, more general scope, for studying the complex process governing physiological aging in humans. Here we give a comprehensive description of the peculiarities related to the breeding of LmnaG609G mice over a prolonged period of time, and of many features observed in a large colony for a 2-years period. We describe the breeding and housing conditions underlining the possible interference of the genetic background on the phenotype expression. This information represents a useful tool when planning and interpreting studies on the LmnaG609G mouse model, complementing any specific data already reported in the literature about this model since its production. It is also particularly relevant for the heterozygous mouse, which mirrors the genotype of the human pathology however requires an extended time to manifest symptoms and to be carefully studied.

中文翻译：

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Lmna G609G早衰小鼠的长期育种：纯合和杂合模型的表征。

转基因LmnaG609G早衰小鼠代表了一种出色的动物模型，用于研究由LMNA基因突变引起的人类Hutchinson-Gilford早衰综合症（HGPS），其编码核被膜蛋白Lamin A / C，并且作为重要的，更通用的范围，用于研究控制人体生理衰老的复杂过程。在这里，我们对与LmnaG609G小鼠长期繁殖有关的特殊性，以及在大型菌落中观察到的许多特征进行了2年的全面描述。我们描述了繁殖和居住条件，强调了遗传背景对表型表达的可能干扰。在规划和解释有关LmnaG609G小鼠模型的研究时，此信息表示一种有用的工具，自该模型生产以来，对文献中已报道的任何特定数据进行了补充。这与杂合小鼠特别相关，杂合小鼠反映了人类病理学的基因型，但是需要更长的时间才能表现出症状并需要仔细研究。