AIMS To describe the annual incidence of type 1 diabetes in children and adolescents insured by the Mexican Institute of Social Security, the main health provider in Mexico, during 2000-2018. METHODS We conducted a secondary data analyses using the incidence registers from the Epidemiological Surveillance Coordination of the Mexican Institute of Social Security collected during 2000-2018. Incident type 1 diabetes cases (age 19 years old and below) were identified using ICD-10-CM E10 diagnostic codes. Age, sex, and geographical region and seasonal-specific incidence were calculated with their corresponding annual percentage change (APC) as well. RESULTS In the period 2000-2018, the number of incident cases with type 1 diabetes decreased from 3.4 to 2.8 per 100,000 in insured for subjects below 20 years old. We observed an increase in the 2000-2006, followed by a decrease for the 2006-2018 period (APC +16.1 and -8.7 respectively). Females and children <5 years old had a significant decrease in the incidence rate, while inhabitants in Central Mexico showed a significant increase. No difference was found in incidence between seasons. CONCLUSIONS Our study describes significant fluctuations of the incidence of type 1 diabetes during the period 2000-2018, which appeared to correspond to influenza outbreaks, among Mexican children and adolescents.

中文翻译：

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墨西哥儿童和青少年的1型糖尿病发病率：来自2000-2018年全国机构注册的数据。

目的描述2000-2018年间由墨西哥主要卫生保健机构墨西哥社会保障研究所（墨西哥）提供的儿童和青少年1型糖尿病的年发病率。方法我们使用2000-2018年期间墨西哥社会保障研究所流行病学监视协调中心的发病率登记表进行了二级数据分析。使用ICD-10-CM E10诊断代码确定了1型糖尿病事件病例（年龄在19岁及以下）。还计算了年龄，性别，地理区域和季节性特定发生率及其相应的年度百分比变化（APC）。结果在2000-2018年期间，年龄在20岁以下的受试者的1型糖尿病的发病例数从100,000人中的3.4下降到2.8。我们观察到2000-2006年期间有所增加，随后2006-2018年期间有所减少（分别为APC +16.1和-8.7）。<5岁的女性和儿童的发病率显着下降，而墨西哥中部的居民则显着上升。各个季节之间的发病率没有差异。结论我们的研究描述了墨西哥儿童和青少年在2000-2018年期间1型糖尿病发病率的显着波动，这似乎与流感的爆发相对应。