Cajal bodies are nuclear organelles involved in the nuclear phase of small nuclear ribonucleoprotein (snRNP) biogenesis. In this study, we identified the splicing factor TCERG1 as a coilin-associated factor that is essential for Cajal body integrity. Knockdown of TCERG1 disrupts the localization of the components of Cajal bodies, including coilin and NOLC1, with coilin being dispersed in the nucleoplasm into numerous small foci, without affecting speckles, gems or the histone locus body. Furthermore, the depletion of TCERG1 affects the recruitment of Sm proteins to uridine-rich small nuclear RNAs (snRNAs) to form the mature core snRNP. Taken together, the results of this study suggest that TCERG1 plays an important role in Cajal body formation and snRNP biogenesis.

中文翻译：

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剪接因子TCERG1在Cajal体完整性和snRNP装配中的作用。

卡哈尔体是参与小核核糖核蛋白（snRNP）生物发生的核相的核细胞器。在这项研究中，我们确定了剪接因子TCERG1是线圈蛋白相关因子，对Cajal身体完整性至关重要。敲除TCERG1会破坏Cajal体成分（包括卷曲蛋白和NOLC1）的定位，而卷曲蛋白则分散在核质中成许多小的病灶，而不会影响斑点，宝石或组蛋白基因座体。此外，TCERG1的消耗会影响Sm蛋白向富尿苷的小核RNA（snRNA）募集以形成成熟的核心snRNP。两者合计，这项研究的结果表明，TCERG1在Cajal体形成和snRNP生物发生中起重要作用。