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Rapid thymectomy of NSG mice to analyze the role of native and grafted thymi in humanized mice.
European Journal of Immunology ( IF 4.5 ) Pub Date : 2019-11-28 , DOI: 10.1002/eji.201948205
Mohsen Khosravi-Maharlooei 1 , Markus Hoelzl 1 , Hao Wei Li 1 , Rachel C Madley 1, 2 , Elizabeth E Waffarn 1 , Nichole M Danzl 1 , Megan Sykes 1, 2, 3
Affiliation  

We developed a rapid method to remove the native mouse thymus from NSG mice, which allowed us to compare the behavior of human immune cells in the presence or absence of human T cells in human immune system mice. Removing the native mouse thymus is critical for studies of human thymopiesis in grafted thymic tissue in humanized mice.

中文翻译:

NSG 小鼠的快速胸腺切除术以分析天然和移植胸腺在人源化小鼠中的作用。

我们开发了一种从 NSG 小鼠中去除天然小鼠胸腺的快速方法,这使我们能够比较人类免疫系统小鼠中存在或不存在人类 T 细胞时人类免疫细胞的行为。去除原生小鼠胸腺对于研究人源化小鼠移植胸腺组织中的人类胸腺发育至关重要。
更新日期:2019-11-29
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