Rapid thymectomy of NSG mice to analyze the role of native and grafted thymi in humanized mice.,European Journal of Immunology

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Rapid thymectomy of NSG mice to analyze the role of native and grafted thymi in humanized mice.
European Journal of Immunology ( IF 4.5 ) Pub Date : 2019-11-28 , DOI: 10.1002/eji.201948205
Mohsen Khosravi-Maharlooei ₁ , Markus Hoelzl ₁ , Hao Wei Li ₁ , Rachel C Madley _{1,

2} , Elizabeth E Waffarn ₁ , Nichole M Danzl ₁ , Megan Sykes _{1,

2,

3}

Affiliation

We developed a rapid method to remove the native mouse thymus from NSG mice, which allowed us to compare the behavior of human immune cells in the presence or absence of human T cells in human immune system mice. Removing the native mouse thymus is critical for studies of human thymopiesis in grafted thymic tissue in humanized mice.

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