Long non-coding RNAs (lncRNAs) are crucial molecules in tumorigenesis and tumor growth in various human cancers, including colorectal cancer (CRC). Studies have revealed that lncRNAs can regulate cellular processes in cancers by interacting with proteins, for example RNA-binding proteins (RBPs). In this study, we recognize a novel lncRNA called LINC01413 that is upregulated in CRC tissues through lncRNAs microarray. Subsequently, we confirmed that an elevated level of LINC01413 expression in CRC tissues was strongly correlated to clinicopathological features, such as tumor size, tumor stage, lymph node metastasis, and distant metastasis, and its association with poor overall survival was also revealed. Additionally, LINC01413 facilitates cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) . Also, silenced LINC01413 restrains tumor growth . Moreover, LINC01413 binds with hnRNP-K and induces YAP1 (yes-associated protein 1)/TAZ1 (tafazzin) nuclear translocation to regulate the expression of ZEB1 in CRC cells. Taken together, this research suggested LINC01413 as a positive regulator in CRC progression through the LINC01413/hnRNP-K/TAZ1/YAP1/ZEB1 axis, broadening a new view on CRC treatment.

中文翻译：

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LINC01413/hnRNP-K/ZEB1 轴通过诱导 YAP1/TAZ1 易位加速结直肠癌中的细胞增殖和 EMT


长非编码RNA（lncRNA）是多种人类癌症（包括结直肠癌（CRC））肿瘤发生和肿瘤生长的关键分子。研究表明，lncRNA 可以通过与蛋白质相互作用来调节癌症中的细胞过程，例如 RNA 结合蛋白 (RBP)。在这项研究中，我们通过 lncRNA 微阵列识别出一种名为 LINC01413 的新型 lncRNA，它在 CRC 组织中表达上调。随后，我们证实CRC组织中LINC01413表达水平升高与肿瘤大小、肿瘤分期、淋巴结转移和远处转移等临床病理特征密切相关，并且还揭示了其与较差的总生存率的相关性。此外，LINC01413 促进细胞增殖、迁移、侵袭和上皮间质转化 (EMT)。此外，沉默的 LINC01413 可抑制肿瘤生长。此外，LINC01413 与 hnRNP-K 结合并诱导 YAP1（yes 相关蛋白 1）/TAZ1（tafazzin）核转位，从而调节 CRC 细胞中 ZEB1 的表达。总而言之，这项研究表明 LINC01413 通过 LINC01413/hnRNP-K/TAZ1/YAP1/ZEB1 轴作为 CRC 进展的正调节因子，拓宽了 CRC 治疗的新观点。