Self-tolerance of T cells is maintained by a combination of thymic negative selection and suppression by T regulatory cells (Tregs); both processes are driven by recognition of self MHC ligands. Treg function ensures that most T cells remain quiescent as naïve cells, but enables some T cells to proliferate and differentiate into cells with a memory phenotype (MP). In this review, we discuss how Tregs shape this compartmentalization of T cells into subsets of naïve and MP T cells.

中文翻译：

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关于T细胞自我耐受的新见解。

通过胸腺阴性选择和T调节细胞（Tregs）的抑制作用，可以维持T细胞的自我耐受性。这两个过程都是由自身MHC配体的识别驱动的。Treg功能可确保大多数T细胞像幼稚细胞一样保持静止，但是使某些T细胞能够增殖并分化为具有记忆表型（MP）的细胞。在这篇综述中，我们讨论了Tregs如何将T细胞的这种区室化转变为纯真的T细胞和MP T细胞的子集。