Previous data obtained in piglets suggested that despite structural analogy with Bisphenol A (BPA), Bisphenol S (BPS) elimination may proceed more slowly, resulting in a much higher systemic exposure to unconjugated BPS than to BPA. Interspecies allometric scaling was applied to predict the toxicokinetic (TK) parameters of BPS, namely plasma clearance in humans from values obtained in animals, and thus contribute to assessment of the human internal exposure to BPS. Allometric scaling was performed using mean BPS plasma clearance values measured in rats after intravenous administration of 5 mg BPS /kg body weight (BW) and those previously obtained in piglets and sheep using identical IV BPS dosing and analytical procedures. The BPS plasma clearance, evaluated at 0.92 L/kg.h in rats, was proportional to species body weight, enabling the prediction of human BPS plasma clearance by extrapolating to a BW of 70 kg. The estimated BPS plasma clearance in humans was thus 0.92 L/min (0.79 L/kg.h), i.e. about two times lower than the previously estimated BPA clearance (1.79 L/min). By increasing systemic exposure to the active moiety of an environmental estrogenic chemical, this less efficient clearance of BPS in humans, as compared with BPA, might worsen the harmful consequences of replacing BPA by BPS.

中文翻译：

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双酚S在大鼠中的毒代动力学，用于从异速结垢中预测人双酚S的清除率。

仔猪获得的先前数据表明，尽管与双酚A（BPA）的结构相似，但双酚S（BPS）的消除过程可能更慢，导致未结合BPS的全身暴露量比BPA高得多。种间异度缩放法用于预测BPS的毒物动力学（TK）参数，即根据从动物获得的值在人体内的血浆清除率，因此有助于评估人体内对BPS的暴露。使用在静脉内施用5 mg BPS / kg体重（BW）后在大鼠中测得的平均BPS血浆清除率值，以及之前使用相同的IV BPS剂量和分析程序在仔猪和绵羊中获得的平均BPS血浆清除率值，进行异速缩放。在大鼠中，BPS血浆清除率为0.92 L / kg.h，与物种体重成正比，通过推断体重为70千克的体重，可以预测人类BPS血浆清除率。因此，估计的人血浆BPS清除率为0.92 L / min（0.79 L / kg.h），即比先前估计的BPA清除率（1.79 L / min）低约两倍。与BPA相比，通过增加对环境雌激素化学物质活性部分的全身暴露，这种对BPS的低效清除可能会加剧用BPS代替BPA的有害后果。