Background Scaling and root planning (SRP) is the gold standard approach for treatment of chronic periodontitis but used alone it may not be effective in removing periodontal pathogens from sites where access is poor. Objective To evaluate and compare the clinical and microbiological efficacy of ozone and chlorhexidine (CHX) as an adjunct to SRP in patients with chronic periodontitis. Methods Twenty-five patients with generalized moderate to severe chronic periodontitis with presence of at least one site in each quadrant with a probing depth ≥5 mm were recruited. In a split mouth study design, two quadrants were randomly allocated to the SRP and ozone therapy and the remaining two quadrants to SRP and CHX therapy. Plaque index (PI), Gingival index (GI), probing depth (PD), clinical attachment loss (CAL) were assessed. Subgingival plaque samples were obtained for assessment of Aggregatibacter actinomycetemcomitans (Aa) and Porphyromonas gingivalis (Pg). Results Both groups demonstrated significant intragroup reduction in PI, GI, PD, CAL, Pg count and Aa count from baseline to 3 months follow-up. There were no significant differences between two groups for any of the parameters. Conclusion Ozonated olive oil can be used as an adjunctive subgingival irrigant in patients with chronic periodontitis.

中文翻译：

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慢性牙周炎患者辅助使用臭氧和氯己定的有效性。

背景 缩放和根部规划 (SRP) 是治疗慢性牙周炎的金标准方法，但单独使用它可能无法有效地从难以进入的部位去除牙周病原体。目的评价和比较臭氧和氯己定（CHX）作为SRP辅助治疗慢性牙周炎患者的临床和微生物学疗效。方法招募25例全身性中重度慢性牙周炎患者，每个象限至少存在一个部位，探诊深度≥5 mm。在分口研究设计中，两个象限被随机分配到 SRP 和臭氧治疗，其余两个象限被随机分配到 SRP 和 CHX 治疗。评估牙菌斑指数（PI）、牙龈指数（GI）、探诊深度（PD）、临床附着损失（CAL）。获得龈下菌斑样本用于评估伴放线菌 (Aa) 和牙龈卟啉单胞菌 (Pg)。结果 两组的 PI、GI、PD、CAL、Pg 计数和 Aa 计数从基线到 3 个月的随访均显着降低。对于任何参数，两组之间没有显着差异。结论 臭氧化橄榄油可作为慢性牙周炎患者的辅助龈下冲洗剂。