White matter microstructural alterations across four major psychiatric disorders: mega-analysis study in 2937 individuals.,Molecular Psychiatry

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White matter microstructural alterations across four major psychiatric disorders: mega-analysis study in 2937 individuals.
Molecular Psychiatry ( IF 9.6 ) Pub Date : 2019-11-29 , DOI: 10.1038/s41380-019-0553-7
Daisuke Koshiyama ₁ , Masaki Fukunaga ₂ , Naohiro Okada _{1,

3} , Kentaro Morita ₁ , Kiyotaka Nemoto ₄ , Kaori Usui ₁ , Hidenaga Yamamori ₅ , Yuka Yasuda _{6,

7} , Michiko Fujimoto ₅ , Noriko Kudo ₇ , Hirotsugu Azechi ₈ , Yoshiyuki Watanabe ₉ , Naoki Hashimoto ₁₀ , Hisashi Narita ₁₀ , Ichiro Kusumi ₁₀ , Kazutaka Ohi _{11,

12} , Takamitsu Shimada ₁₁ , Yuzuru Kataoka ₁₁ , Maeri Yamamoto ₁₃ , Norio Ozaki ₁₃ , Go Okada ₁₄ , Yasumasa Okamoto ₁₄ , Kenichiro Harada ₁₅ , Koji Matsuo ₁₆ , Hidenori Yamasue ₁₇ , Osamu Abe ₁₈ , Ryuichiro Hashimoto ₁₉ , Tsutomu Takahashi ₂₀ , Tomoki Hori ₂₁ , Masahito Nakataki ₂₂ , Toshiaki Onitsuka ₂₃ , Laurena Holleran ₂₄ , Neda Jahanshad ₂₅ , Theo G M van Erp ₂₆ , Jessica Turner ₂₇ , Gary Donohoe ₂₄ , Paul M Thompson ₂₅ , Kiyoto Kasai _{1,

3} , Ryota Hashimoto _{5,

7,

8} ,

Affiliation

Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Division of Cerebral Integration, National Institute for Physiological Sciences, Aichi, Japan.
International Research Center for Neurointelligence (WPI-IRCN), UTIAS, The University of Tokyo, Tokyo, Japan.
Department of Psychiatry, Division of Clinical Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Japan.
Life Grow Brilliant Mental Clinic, Medical Corporation Foster, Osaka, Japan.
Department of Pathology of Mental Diseases, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan.
Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Osaka, Japan.
Diagnostic and Interventional Radiology, Osaka University Graduate School of Medicine, Osaka, Japan.
Department of Psychiatry, Hokkaido University Graduate School of Medicine, Hokkaido, Japan.
Department of Neuropsychiatry, Kanazawa Medical University, Ishikawa, Japan.
Medical Research Institute, Kanazawa Medical University, Ishikawa, Japan.
Department of Psychiatry, Nagoya University, Graduate School of Medicine, Aichi, Japan.
Department of Psychiatry and Neurosciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan.
Department of Psychiatry, Faculty of Medicine, Saitama Medical University, Saitama, Japan.
Department of Psychiatry, Hamamatsu University School of Medicine, Shizuoka, Japan.
Department of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Medical Institute of Developmental Disabilities Research, Showa University, Tokyo, Japan.
Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, Toyama, Japan.
Department of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Department of Psychiatry, Tokushima University Hospital, Tokushima, Japan.
Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Center for Neuroimaging and Cognitive Genomics (NICOG), School of Psychology, National University of Ireland Galway, Galway, Ireland.
Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Clinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA, USA.
Psychology and Neuroscience, Georgia State University, Atlanta, GA, USA.

Identifying both the commonalities and differences in brain structures among psychiatric disorders is important for understanding the pathophysiology. Recently, the ENIGMA-Schizophrenia DTI Working Group performed a large-scale meta-analysis and reported widespread white matter microstructural alterations in schizophrenia; however, no similar cross-disorder study has been carried out to date. Here, we conducted mega-analyses comparing white matter microstructural differences between healthy comparison subjects (HCS; N = 1506) and patients with schizophrenia (N = 696), bipolar disorder (N = 211), autism spectrum disorder (N = 126), or major depressive disorder (N = 398; total N = 2937 from 12 sites). In comparison with HCS, we found that schizophrenia, bipolar disorder, and autism spectrum disorder share similar white matter microstructural differences in the body of the corpus callosum; schizophrenia and bipolar disorder featured comparable changes in the limbic system, such as the fornix and cingulum. By comparison, alterations in tracts connecting neocortical areas, such as the uncinate fasciculus, were observed only in schizophrenia. No significant difference was found in major depressive disorder. In a direct comparison between schizophrenia and bipolar disorder, there were no significant differences. Significant differences between schizophrenia/bipolar disorder and major depressive disorder were found in the limbic system, which were similar to the differences in schizophrenia and bipolar disorder relative to HCS. While schizophrenia and bipolar disorder may have similar pathological characteristics, the biological characteristics of major depressive disorder may be close to those of HCS. Our findings provide insights into nosology and encourage further investigations of shared and unique pathophysiology of psychiatric disorders.

中文翻译：

四种主要精神疾病的白质微结构改变：对 2937 人进行的大型分析研究。

识别精神疾病之间大脑结构的共性和差异对于理解病理生理学很重要。最近，ENIGMA-Schizophrenia DTI 工作组进行了大规模的荟萃分析，报告了精神分裂症中广泛的白质微结构改变；然而，迄今为止还没有进行过类似的交叉疾病研究。在这里，我们进行了大型分析，比较了健康对照受试者（HCS；N = 1506）和精神分裂症患者（N = 696）、双相情感障碍（N = 211）、自闭症谱系障碍（N = 126）之间的白质微结构差异，或重度抑郁症（N = 398；来自 12 个站点的总 N = 2937）。与 HCS 相比，我们发现精神分裂症、双相情感障碍、和自闭症谱系障碍在胼胝体中具有相似的白质微结构差异；精神分裂症和双相情感障碍的特点是边缘系统发生了类似的变化，例如穹窿和扣带回。相比之下，仅在精神分裂症中观察到连接新皮质区域的束（例如钩束）的改变。在重度抑郁症中没有发现显着差异。在精神分裂症和双相情感障碍之间的直接比较中，没有显着差异。在边缘系统中发现精神分裂症/双相情感障碍与重度抑郁症之间存在显着差异，这与精神分裂症和双相情感障碍相对于HCS的差异相似。虽然精神分裂症和双相情感障碍可能具有相似的病理特征，重度抑郁症的生物学特征可能与 HCS 相近。我们的研究结果提供了对疾病学的见解，并鼓励进一步研究共同和独特的精神疾病病理生理学。

更新日期：2019-11-29

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