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Proteomic and Metabolic Elucidation of Solar-Powered Biomanufacturing by Bio-Abiotic Hybrid System
Chem ( IF 18.205 ) Pub Date : 2019-11-28 , DOI: 10.1016/j.chempr.2019.11.002
Rutan Zhang, Ying He, Jia Yi, Lijuan Zhang, Chengpin Shen, Shujuan Liu, Lifeng Liu, Baohong Liu, Liang Qiao

Highly efficient inorganic light absorbers combined with highly specific biocatalysts, i.e., chemolithoautotrophic microbes, have recently been proposed for solar-powered biomanufacturing to pave the way in artificial photosynthesis. In this work, we studied the global protein and metabolite changes of a Moorella thermoacetica-CdS (cadmium sulfide quantum dots) hybrid system during light harvesting. The Wood-Ljungdahl pathway (WLP) that has been considered as the main approach for CO2 fixation was found to be highly activated by CdS. Targeted metabolite quantification revealed that energy-metabolism-associated glycolysis and the tricarboxylic acid (TCA) cycle were also activated. Therefore, we propose an energy-conservation scheme to the M. thermoacetica-CdS hybrid system, i.e., glycolysis and the TCA cycle along with the oxidation of acetyl-coenzyme A (CoA) and NADH, in addition to the well-documented chemiosmotic proton gradient-driven ATP production by ATPase. We expect that the study can be helpful to guide the design of effective and biocompatible photo-biocatalytic systems in the future.
更新日期:2019-11-29

 

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