Transition-metal-free lactamization of C(sp3)–H bonds with CO2: facile generation of pyrido[1,2-a]pyrimidin-4-ones†,Green Chemistry

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Transition-metal-free lactamization of C(sp3)–H bonds with CO2: facile generation of pyrido[1,2-a]pyrimidin-4-ones†
Green Chemistry ( IF 9.3 ) Pub Date : 2019-11-28 , DOI: 10.1039/c9gc03659h
Zhen Zhang _{1,

2,

3,

4,

5} , Xiao-Yu Zhou _{5,

6,

7,

8,

9} , Jin-Gui Wu _{5,

6,

7,

8,

9} , Lei Song _{5,

6,

7,

8,

9} , Da-Gang Yu _{5,

6,

7,

8,

9}

Affiliation

A novel carbonylation of C(sp³)–H bonds in pyridylamines with one atmosphere of CO₂ is reported to synthesize important pyrimidinones in good yields. This transition-metal-free and redox-neutral process features the use of a nontoxic carbonyl source, broad substrate scope, good functional group tolerance, facile scalability and easy product derivatization.

中文翻译：

C（sp ³）-H键与CO ₂的无过渡金属内酰胺化：吡啶基[1,2 - a ]嘧啶-4-酮的便捷生成†

据报道，吡啶胺中C（sp ³）-H键在一种CO ₂气氛下的新型羰基化反应以高收率合成了重要的嘧啶酮。这种无过渡金属和氧化还原中性的方法的特点是使用无毒的羰基来源，广泛的底物范围，良好的官能团耐受性，易扩展性和易于产品衍生化。

更新日期：2020-01-02

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