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Neuropsychological decline up to 20 years before incident mild cognitive impairment
Alzheimer's & Dementia ( IF 13.0 ) Pub Date : 2020-01-06 , DOI: 10.1016/j.jalz.2019.09.085
Richard J Caselli 1 , Blake T Langlais 2 , Amylou C Dueck 2 , Yinghua Chen 3 , Yi Su 3 , Dona E C Locke 4 , Bryan K Woodruff 1 , Eric M Reiman 3
Affiliation  

Some Alzheimer's disease biomarker studies found amyloid changes 20 years or more in advance of expected symptoms, while cognitive changes lagged for more than a decade, but this apparent lag might reflect the sensitivities of the biomarker and cognitive assays used. How far in advance of incident amnestic mild cognitive impairment (MCI) does cognition begin to decline?

中文翻译:


轻度认知障碍发生前 20 年神经心理衰退



一些阿尔茨海默病生物标志物研究发现,淀粉样蛋白的变化比预期症状提前 20 年或更长时间,而认知变化则滞后了十多年,但这种明显的滞后可能反映了所用生物标志物和认知测定的敏感性。遗忘性轻度认知障碍 (MCI) 发生前多久认知能力开始下降?
更新日期:2020-01-06
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