Obesity: a neuroimmunometabolic perspective.,Nature Reviews Endocrinology

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Obesity: a neuroimmunometabolic perspective.
Nature Reviews Endocrinology ( IF 31.0 ) Pub Date : 2019-11-27 , DOI: 10.1038/s41574-019-0283-6
Chelsea M Larabee ₁ , Oliver C Neely ₁ , Ana I Domingos _{1,

2}

Affiliation

Neuroimmunology and immunometabolism are burgeoning topics of study, but the intersection of these two fields is scarcely considered. This interplay is particularly prevalent within adipose tissue, where immune cells and the sympathetic nervous system (SNS) have an important role in metabolic homeostasis and pathology, namely in obesity. In the present Review, we first outline the established reciprocal adipose-SNS relationship comprising the neuroendocrine loop facilitated primarily by adipose tissue-derived leptin and SNS-derived noradrenaline. Next, we review the extensive crosstalk between adipocytes and resident innate immune cells as well as the changes that occur in these secretory and signalling pathways in obesity. Finally, we discuss the effect of SNS adrenergic signalling in immune cells and conclude with exciting new research demonstrating an immutable role for SNS-resident macrophages in modulating SNS-adipose crosstalk. We posit that the latter point constitutes the existence of a new field - neuroimmunometabolism.

中文翻译：

肥胖：神经免疫代谢的观点。

神经免疫学和免疫代谢是新兴的研究课题，但很少考虑这两个领域的交叉点。这种相互作用在脂肪组织中尤为普遍，其中免疫细胞和交感神经系统 (SNS) 在代谢稳态和病理学（即肥胖）中具有重要作用。在本综述中，我们首先概述了已建立的相互脂肪-SNS 关系，包括主要由脂肪组织衍生的瘦素和 SNS 衍生的去甲肾上腺素促进的神经内分泌环。接下来，我们回顾了脂肪细胞和常驻先天免疫细胞之间的广泛串扰，以及肥胖中这些分泌和信号通路发生的变化。最后，我们讨论了 SNS 肾上腺素能信号在免疫细胞中的作用，并以令人兴奋的新研究结束，证明 SNS 驻留巨噬细胞在调节 SNS-脂肪串扰中具有不可改变的作用。我们假设后一点构成了一个新领域的存在——神经免疫代谢。

更新日期：2019-11-28

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