OBJECTIVE To evaluate trabecular bone score (TBS) in Spanish postmenopausal women from our area. To analyze its relationship with bone mineral density (BMD), bone quantitative ultrasound (QUS) and serum concentrations of 25-hydroxyvitamin D (25(OH)D), intact parathyroid hormone (PTH) and bone turnover markers. STUDY DESIGN A total of 1450 postmenopausal women aged 44-94 (62 ± 10) participated in this cross-sectional study nested in a population-based cohort. BMD and TBS were assessed by DXA. QUS measurements were performed using a Sahara Clinical Sonometer. Serum 25(OH)D, PTH, P1NP, β-CTX were determined by electrochemiluminescence. RESULTS Mean TBS of postmenopausal women in our region was 1.341 ± 0.111. Nearly 50 % of them had normal values. Only 11 % had scores compatible with a clearly degraded microarchitecture. TBS decreased with age, correlated negatively with BMI and was lower in current smokers than in non-smokers. An association was observed between TBS and QUS, although the association was weak and lower than that found between TBS and BMD or QUS and BMD. No association was found between TBS and 25(OH)D, PTH or bone turnover markers. CONCLUSIONS Half of postmenopausal women in our region have TBS values that indicate a preserved microarchitecture. Only about 10 % have scores compatible with a clearly degraded microarchitecture. A weak association was observed between TBS and QUS, suggesting that the two techniques capture different aspects of bone microarchitecture. The absence of association with 25(OH)D, PTH, and bone turnover markers may be due to the fact that TBS assesses a specific (mostly trabecular) part of the skeleton, whilst the three serum factors are related to the whole skeleton.

中文翻译：

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西班牙绝经后妇女的骨小梁评分和骨定量超声。Camargo 队列研究

目的 评估我们地区西班牙绝经后妇女的骨小梁评分 (TBS)。分析其与骨密度（BMD）、骨定量超声（QUS）和血清25-羟基维生素D（25（OH）D）浓度、完整甲状旁腺激素（PTH）和骨转换标志物的关系。研究设计 共有 1450 名年龄在 44-94 岁之间 (62 ± 10) 的绝经后妇女参加了这项横断面研究，该研究嵌套在基于人群的队列中。BMD 和 TBS 由 DXA 评估。QUS 测量是使用 Sahara Clinical Sonometer 进行的。血清 25(OH)D、PTH、P1NP、β-CTX 通过电化学发光测定。结果 我们地区绝经后妇女的平均 TBS 为 1.341 ± 0.111。其中近 50% 具有正常值。只有 11% 的分数与明显降级的微架构兼容。TBS随着年龄的增长而下降，与 BMI 呈负相关，并且在当前吸烟者中低于非吸烟者。在 TBS 和 QUS 之间观察到关联，尽管关联较弱且低于 TBS 和 BMD 或 QUS 和 BMD 之间的关联。未发现 TBS 与 25(OH)D、PTH 或骨转换标志物之间存在关联。结论 我们地区半数绝经后妇女的 TBS 值表明微结构得以保留。只有大约 10% 的分数与明显降级的微体系结构兼容。在 TBS 和 QUS 之间观察到弱关联，表明这两种技术捕获了骨微结构的不同方面。与 25(OH)D、PTH 和骨转换标志物没有关联可能是因为 TBS 评估骨骼的特定（主要是小梁）部分，