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Rapid detection of human herpes virus by next-generation sequencing in a patient with encephalitis.
Virology Journal ( IF 4.0 ) Pub Date : 2019-08-17 , DOI: 10.1186/s12985-019-1205-x
Yu Zhang 1 , Kun Hong 1 , Yueli Zou 1 , Hui Bu 1
Affiliation  

BACKGROUND The inflammatory or non-inflammatory changes caused by the virus entering the nervous system and related tissues are central nervous system virus infections. Viral infection is a common infectious disease of the central nervous system, of which herpes simplex virus encephalitis is the most common. However, conventional laboratory techniques to detect an infectious agent are difficult to achieve etiological diagnosis. CASE PRESENTATION Here we present a patient with severe and progressive encephalitis, requiring diagnosis of the specific pathogen to guide clinical treatments. CONCLUSIONS Application of next-generation sequencing provided a quick and definite diagnosis of the etiology of encephalitis and enabled our patient to be treated appropriately.

中文翻译:

通过下一代测序快速筛查脑炎患者的人疱疹病毒。

背景技术由病毒进入神经系统和相关组织引起的炎性或非炎性变化是中枢神经系统病毒感染。病毒感染是中枢神经系统的常见传染病,其中单纯疱疹病毒性脑炎是最常见的。然而,检测病原的常规实验室技术难以实现病因学诊断。病例介绍在这里,我们介绍了患有严重和进行性脑炎的患者,需要对特定病原体进行诊断以指导临床治疗。结论下一代测序的应用为脑炎的病因学提供了快速而明确的诊断,并使我们的患者得到适当治疗。
更新日期:2019-08-17
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