BACKGROUND Human papillomavirus (HPV) is one of the most common sexually transmitted viruses. Data about HPV infection in Guizhou is limited. METHODS 56,768 cervical samples were collected and genotyped for 15 main high risk and 6 main low risk HPV types. RESULTS 16.95% (9623/56768) of samples were HPV positive; 90.70% (8728/9623) of HPV positive women were infected by high risk HPV. High risk and high risk mix infection (1458; 70.85%) was the most common mix HPV infection type. The highest HPV detection rate was found in age group 41-45 years old (detection rate = 17.89%) (χ2 = 204.77; P < 0.001); the highest within-group HPV infection rates were found in the ≤20 (25.62%) and ≥ 61 (24.67%) years old age groups, the lowest within-group HPV infection rate was found in the 31-35 years old age group (15.02%). The highest mix infection proportions were found in the ≥61 (36.06%) and ≤ 20 (33.63%) years old age groups (χ2 = 111.21; P < 0.001), the lowest mix infection proportion was found in the 41-45 (17.42%) years old age group. The highest high risk infection proportions were found in the 26-30 (92.98%), ≥61 (92.68%), and 36-40 (92.16%) years old age groups (χ2 = 31.72; P < 0.001), the lowest high risk infection proportion was found in the ≤20 (84.96%) years old age group. HPV infection rates varied with seasons in Guizhou. CONCLUSIONS Characteristics of HPV distribution in Guizhou were identified. There were significant differences in HPV distribution among age groups, prevention strategies should be adjusted according to the characteristics.

中文翻译：

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贵州省人乳头瘤病毒分布特征.

背景技术人乳头瘤病毒(HPV)是最常见的性传播病毒之一。有关贵州 HPV 感染的数据有限。方法 收集了 56,768 份宫颈样本，并对 15 种主要高危型和 6 种主要低危型 HPV 进行了基因分型。结果 16.95% (9623/56768) 的样本呈 HPV 阳性；90.70%（8728/9623）的HPV阳性女性感染了高危HPV。高危和高危混合感染（1458；70.85%）是最常见的混合HPV感染类型。41-45岁年龄段HPV检出率最高（检出率=17.89%）（χ2=204.77；P<0.001）；组内HPV感染率最高的是≤20岁（25.62%）和≥61岁（24.67%）年龄组，组内HPV感染率最低的是31-35岁年龄组（ 15.02%）。混合感染比例最高的是≥61岁（36.06%）和≤20岁（33.63%）年龄组（χ2 = 111.21；P < 0.001），混合感染比例最低的是41~45岁（17.42）。 %) 岁年龄组。26-30岁（92.98%）、≥61岁（92.68%）和36-40岁（92.16%）年龄组高危感染比例最高（χ2 = 31.72；P < 0.001），高风险感染比例最低。 ≤20岁年龄组存在感染风险比例（84.96%）。贵州省HPV感染率随季节变化。结论 明确了贵州省HPV的分布特征。HPV在不同年龄段的分布存在显着差异，应根据特点调整预防策略。