BACKGROUND N6-methyladenosine (m6A) modification is the most prevalent internal modification of eukaryotic mRNA modulating gene expression. m6A modification is a dynamic reversible process regulated by three protein groups: methyltransferases (writers), demethylases (erasers), and m6A-binding proteins (readers). m6A modification is involved in all phases of RNA metabolism, including RNA folding, stability, splicing, nuclear exporting, translational modulation and degradation. MAIN BODY In recent years, numerous studies have reported that abnormal m6A modification causes aberrant expression of important viral genes. Herein, we review the role of m6A in viral lifecycle and its contribution to the pathogenesis of human diseases. Particularly, we focus on the viruses associated with human diseases such as HIV-1, IAV, HBV, HCV, EBV and many others. CONCLUSIONS A better understanding of m6A-virus relationship would provide new insights into the viral replication process and pathogenesis of human diseases caused by viruses. In addition, exploration of the role of m6A in disease-causing viruses will reveal novel approaches for the treatment of such diseases.

中文翻译：

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N6-甲基腺苷与病毒和相关疾病的关联。

背景 N6-甲基腺苷 (m6A) 修饰是调节基因表达的真核 mRNA 最普遍的内部修饰。m6A 修饰是一个动态可逆过程，由三个蛋白质组调节：甲基转移酶（写入器）、去甲基化酶（擦除器）和 m6A 结合蛋白（读取器）。m6A 修饰涉及 RNA 代谢的所有阶段，包括 RNA 折叠、稳定性、剪接、核输出、翻译调节和降解。主体 近年来，大量研究报道异常 m6A 修饰导致重要病毒基因的异常表达。在此，我们回顾了 m6A 在病毒生命周期中的作用及其对人类疾病发病机制的贡献。我们特别关注与人类疾病相关的病毒，例如 HIV-1、IAV、HBV、HCV、EBV 等。结论 更好地了解 m6A 与病毒的关系将为病毒复制过程和由病毒引起的人类疾病的发病机制提供新的见解。此外，探索 m6A 在致病病毒中的作用将揭示治疗此类疾病的新方法。