BackgroundMigraine is a disabling, chronic neurological disease leading to severe headache episodes affecting 13.2% of the Swedish population. Migraine leads to an extensive socio-economic burden in terms of healthcare costs, reduced workforce and quality of life (QoL) but studies of the health-economic consequences in a Swedish context are lacking.The objective of this study is to map the health-economic consequences of migraine in a defined patient population in terms of healthcare consumption, production loss and QoL in Sweden.MethodsThe study is based on data from a web-based survey to members in the Swedish patients’ association suffering from migraine. The survey was conducted in May 2018 and included people with migraine aged 18 years or older. The survey included questions on health resource consumption, lost production resulting from migraine-related absenteeism and presenteeism, and QoL as measured by the EuroQol 5 dimensions questionnaire (EQ-5D-5 L) and the Headache Impact Test (HIT-6). The results are presented in yearly costs per patient and losses in quality adjusted life years (QALYs).ResultsThe results are based on answers from 630 individuals with migraine and are presented by number of migraine days per month. The total cost per patient and year increased with the number of migraine days per month (p < 0.001) and varied between approximately €5000 for those with less than 3 migraine days per month and €24,000 per year for those with 21–28 migraine days per month. Production loss represented the main part of the costs, approximately 80%. The average loss in QALYs per year also increased with the monthly number of migraine days (p = 0.023).ConclusionsMigraine leads to significant societal costs and loss of quality of life. There appears to be an unmet need and a potential for both cost savings and QoL benefits connected with a reduction in the number of migraine days.

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瑞典定义的患者人群中偏头痛的负担和费用——一项基于问卷的研究

背景偏头痛是一种致残的慢性神经系统疾病，会导致严重的头痛发作，影响 13.2% 的瑞典人口。偏头痛在医疗保健成本、劳动力减少和生活质量 (QoL) 方面导致广泛的社会经济负担，但缺乏瑞典背景下对健康经济后果的研究。本研究的目的是绘制健康-就瑞典的医疗保健消费、生产损失和 QoL 而言，偏头痛在特定患者群体中的经济后果。方法本研究基于对瑞典偏头痛患者协会成员的网络调查数据。该调查于 2018 年 5 月进行，包括 18 岁或以上的偏头痛患者。调查包括关于卫生资源消耗的问题，由偏头痛相关的缺勤和出勤导致的生产损失，以及通过 EuroQol 5 维度问卷 (EQ-5D-5 L) 和头痛影响测试 (HIT-6) 测量的 QoL。结果以每位患者的年成本和质量调整生命年 (QALYs) 的损失表示。结果结果基于 630 名偏头痛患者的回答，并以每月偏头痛天数表示。每名患者和每年的总费用随着每月偏头痛天数的增加而增加（p < 0.001），每月偏头痛天数少于 3 天的患者约为 5000 欧元，偏头痛天数为 21-28 天的患者每年为 24,000 欧元每月。生产损失占成本的主要部分，约占80%。每年 QALYs 的平均损失也随着每月偏头痛天数的增加而增加（p = 0. 023).结论偏头痛导致显着的社会成本和生活质量的损失。似乎存在未满足的需求，并且有可能通过减少偏头痛天数来节省成本和获得 QoL 收益。