BackgroundMigraine is a common debilitating condition whose main attributes are severe recurrent headaches with accompanying sensitivity to light and sound, nausea and vomiting. Migraine-related pain is a major cause of its accompanying disability and can encumber almost every aspect of daily life.Main bodyAdvancements in our understanding of the neurobiology of migraine headache have come in large from basic science research utilizing small animal models of migraine-related pain. In this current review, we aim to describe several commonly utilized preclinical models of migraine. We will discuss the diverse array of methodologies for triggering and measuring migraine-related pain phenotypes and highlight briefly specific advantages and limitations therein. Finally, we will address potential future challenges/opportunities to refine existing and develop novel preclinical models of migraine that move beyond migraine-related pain and expand into alternate migraine-related phenotypes.ConclusionSeveral well validated animal models of pain relevant for headache exist, the researcher should consider the advantages and limitations of each model before selecting the most appropriate to answer the specific research question. Further, we should continually strive to refine existing and generate new animal and non-animal models that have the ability to advance our understanding of head pain as well as non-pain symptoms of primary headache disorders.

中文翻译：

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偏头痛动物模型和用于检查三叉神经感觉处理的实验技术

背景偏头痛是一种常见的使人衰弱的疾病，其主要特征是严重的反复性头痛，伴有对光和声音的敏感性、恶心和呕吐。偏头痛相关疼痛是其伴随残疾的主要原因，并且几乎可以影响日常生活的方方面面。主体我们对偏头痛神经生物学的理解在很大程度上来自利用偏头痛相关疼痛的小动物模型进行的基础科学研究. 在本次审查中，我们旨在描述几种常用的偏头痛临床前模型。我们将讨论触发和测量偏头痛相关疼痛表型的各种方法，并简要强调其中的具体优势和局限性。最后，我们将解决潜在的未来挑战/机遇，以改进现有的和开发新的偏头痛临床前模型，超越偏头痛相关的疼痛并扩展到其他偏头痛相关的表型。结论存在一些经过充分验证的与头痛相关的疼痛动物模型，研究人员应该考虑在选择最适合回答具体研究问题之前，先了解每种模型的优点和局限性。此外，我们应该不断努力改进现有的并生成新的动物和非动物模型，这些模型能够促进我们对头部疼痛以及原发性头痛疾病的非疼痛症状的理解。结论 存在几种经过充分验证的与头痛相关的疼痛动物模型，研究人员应考虑每种模型的优点和局限性，然后再选择最适合回答具体研究问题的模型。此外，我们应该不断努力改进现有的并生成新的动物和非动物模型，这些模型能够促进我们对头部疼痛以及原发性头痛疾病的非疼痛症状的理解。结论 存在几种经过充分验证的与头痛相关的疼痛动物模型，研究人员应考虑每种模型的优点和局限性，然后再选择最适合回答具体研究问题的模型。此外，我们应该不断努力改进现有的并生成新的动物和非动物模型，这些模型能够促进我们对头部疼痛以及原发性头痛疾病的非疼痛症状的理解。