BACKGROUND Interpersonal psychotherapy (IPT) is an intervention that has established efficacy in the prevention and treatment of depressive disorders. Previous systematic reviews have not evaluated the effectiveness of IPT on symptoms of stress, anxiety, depression, quality of life, relationship satisfaction/quality, social supports, and an improved psychological sense of well-being. There is limited data regarding factors that moderate and mediate the effectiveness of IPT including the timing of the intervention or the mode of delivery of IPT intervention. The objective of this systematic review and meta-analysis is to evaluate the effectiveness, feasibility, and acceptability of IPT interventions to treat perinatal psychological distress and to summarize the evidence on predictors, mediators, and moderators of IPT. METHODS We will include peer-reviewed studies that recruited perinatal women. The search strategy will involve the following databases: MEDLINE (Ovid), EMBASE (Ovid), PsycINFO (Ovid), Cochrane Central Register of Controlled Trials (Ovid), CINAHL with Full Text (EBSCO), Social Work Abstracts (EBSCO), SocINDEX with Full Text (EBSCO), Academic Search Complete (EBSCO), Family & Society Studies Worldwide (EBSCO), Family Studies Abstracts (EBSCO), and Scopus. Study inclusion criteria include (1) randomized controlled trials, quasi-experimental studies, and pre-post studies that evaluated the effectiveness of IPT; (2) qualitative studies that evaluated feasibility and acceptability of IPT; (3) study sample included and analyzed perinatal women; and (4) publication language was English. Using pilot-tested screening and data extraction forms, two reviewers will independently review studies in three steps: (1) abstract/title screening, (2) full-text screening of potentially accepted studies, and (3) data extraction of accepted studies. Disagreements will be resolved by a third reviewer. Studies will be aggregated for meta-synthesis and meta-analysis should the data allow for this. Two independent reviewers will grade methodological quality. DISCUSSION Findings from this review will inform future development and implementation of IPT intervention research for perinatal women. Identifying key factors of successful IPT interventions will inform intervention design and adaptation of IPT interventions to increase the likelihood that perinatal women will engage in and benefit from IPT interventions. This review will also identify key considerations for increasing the effectiveness of IPT interventions during the perinatal period. SYSTEMATIC REVIEW REGISTRATION PROSPERO CRD42019114292.

中文翻译：

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围产期妇女的人际心理治疗：系统评价和荟萃分析方案。

背景技术人际心理治疗（IPT）是一种在预防和治疗抑郁症方面已证实有效的干预措施。之前的系统评价尚未评估 IPT 对压力、焦虑、抑郁、生活质量、关系满意度/质量、社会支持和改善心理幸福感症状的有效性。关于调节和介导 IPT 有效性的因素（包括干预时间或 IPT 干预的实施方式）的数据有限。本系统评价和荟萃分析的目的是评估 IPT 干预措施治疗围产期心理困扰的有效性、可行性和可接受性，并总结 IPT 预测因素、中介因素和调节因素的证据。方法 我们将纳入招募围产期妇女的同行评审研究。检索策略将涉及以下数据库：MEDLINE (Ovid)、EMBASE (Ovid)、PsycINFO (Ovid)、Cochrane Central Register of Controlled Trials (Ovid)、CINAHL with Full Text (EBSCO)、Social Work Abstracts (EBSCO)、SocINDEX包括全文 (EBSCO)、学术检索完成 (EBSCO)、全球家庭与社会研究 (EBSCO)、家庭研究摘要 (EBSCO) 和 Scopus。研究纳入标准包括（1）评估IPT有效性的随机对照试验、准实验研究和事前研究；(2) 评估IPT可行性和可接受性的定性研究；(3) 研究样本纳入并分析围产期妇女；(4)出版语言为英文。使用试点筛选和数据提取表格，两名评审员将分三个步骤独立评审研究：（1）摘要/标题筛选，（2）潜在接受研究的全文筛选，以及（3）接受研究的数据提取。分歧将由第三位评审员解决。如果数据允许，研究将被汇总以进行荟萃综合和荟萃分析。两名独立评审员将对方法学质量进行评分。讨论 本次综述的结果将为围产期妇女 IPT 干预研究的未来发展和实施提供信息。确定成功 IPT 干预措施的关键因素将为干预设计和 IPT 干预措施的调整提供信息，以增加围产期妇女参与 IPT 干预措施并从中受益的可能性。本次审查还将确定提高围产期 IPT 干预有效性的关键考虑因素。系统审查注册 PROSPERO CRD42019114292。