BACKGROUND Inflammation and elevated blood lipids are associated with infertility. Aspirin and statin therapy may improve infertility treatment outcomes among overweight and obese women with systemic inflammation, but little is known about the short-term effects of statins in this population. We conducted a pilot study of aspirin, pravastatin, or combined treatment among a group of overweight and obese, reproductive-aged women. Our goal was to characterize short-term changes in inflammatory and lipid biomarkers during and after treatment. METHODS In this open-label trial, women aged 18-40 years with a body mass index ≥25 kg/m2 were randomized to receive either 162 mg aspirin, 40 mg pravastatin, or both. The study medication was taken daily for 2 weeks, and participants were then followed for a two-week washout period. Participants provided blood samples at baseline, after the intervention period, and after the washout period. The outcomes were changes in biomarkers of inflammation and lipids measured in blood components at each timepoint. RESULTS Nine, 8, and 8 women were randomized to the aspirin, pravastatin, and combined arms, respectively. Analyses were conducted among 8, 7, and 7 women in the aspirin, pravastatin, and combined arms for whom biomarker data was available at baseline. High-sensitivity C-reactive protein (hsCRP) levels were lower after treatment in all arms and continued to decrease after washout in the pravastatin and combined arms. Results were consistent between the whole sample and women with baseline hsCRP between 2 and 10 mg/L. Low-density lipoprotein (LDL) cholesterol was lower after treatment in the pravastatin and combined arms and rose slightly after washout. CONCLUSIONS Our results provide preliminary evidence that short-term aspirin and pravastatin therapy reduces hsCRP and LDL cholesterol among overweight and obese women of reproductive age, including those with low-grade inflammation. Because of these short-term effects, these drugs may improve infertility treatment outcomes in this population, which we will assess in a future randomized trial.

中文翻译：

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阿司匹林和普伐他汀治疗期间和之后炎症和血脂水平短期变化的随机随机试验。

背景技术发炎和血脂升高与不孕症有关。阿司匹林和他汀类药物疗法可改善患有系统性炎症的超重和肥胖女性的不孕症治疗结果，但对于他汀类药物在该人群中的短期作用知之甚少。我们对一组超重和肥胖的育龄妇女进行了阿司匹林，普伐他汀或联合治疗的初步研究。我们的目标是表征治疗期间和治疗后炎症和脂质生物标志物的短期变化。方法在这项开放性试验中，体重指数≥25kg / m2的18-40岁女性被随机分配接受162 mg阿司匹林，40 mg普伐他汀或两者均接受。每天服用研究药物2周，然后对参与者进行为期2周的冲洗。参与者在基线，干预期之后和冲洗期之后提供了血液样本。结果是在每个时间点测量的血液成分中炎症和脂质的生物标志物的变化。结果分别有9名，8名和8名妇女随机接受阿司匹林，普伐他汀和联合用药。在阿司匹林，普伐他汀和联合用药组中的8名，7名和7名妇女中进行了分析，这些妇女在基线时可获得其生物标志物数据。治疗后，所有组的高敏C反应蛋白（hsCRP）水平均降低，而普伐他汀和联合组的冲洗后，高敏感性C反应蛋白水平持续降低。整个样本与基线hsCRP在2至10 mg / L之间的女性之间的结果是一致的。在普伐他汀和联合用药中，低密度脂蛋白（LDL）胆固醇治疗后较低，而冲洗后则略有上升。结论我们的结果提供了初步的证据，即短期的阿司匹林和普伐他汀治疗可降低超重和肥胖育龄妇女（包括低度炎症患者）的hsCRP和LDL胆固醇。由于这些短期作用，这些药物可能会改善该人群的不育治疗结果，我们将在以后的随机试验中对其进行评估。