Many infertility specialists support the existence of a relationship between the levels of mitochondrial DNA and the quality of the blastocysts. Despite the extensive use of pre-implantation genetic testing for aneuploidy, a significant percentage of euploid embryos do not implant even though the endometrium is normal. Mitochondrial DNA may be used as a new test in evaluating embryonic vitality.Ovarian aging leads to a decrease in the quantity and quality of oocytes and aged oocytes have a reduced number of mitochondria. Mitochondria are the energy factories of the cells and their lacked could leads to lower fertilization rates and poor embryonic development. Various strategies have been tested to increase the mitochondria quantity and thus improve the quality of oocytes used in in vitro fertilization. Results of ovarian rejuvenation techniques such as autologous mitochondrial transplantation have been controversial. In this review, we describe the state of the art concerning the use of mitochondrial DNA and autologous mitochondrial transplantation as new possibilities to increase success in vitro fertilization.

中文翻译：

---

体外受精的新领域：mtDNA和自体生殖系线粒体能量转移。

许多不育专家支持线粒体DNA水平与胚泡质量之间存在联系。尽管为非整倍性广泛使用了植入前基因测试，但即使子宫内膜正常，仍有相当大比例的整倍体胚胎没有植入。线粒体DNA可作为评估胚胎活力的新方法。卵巢衰老导致卵母细胞数量和质量下降，而老化的卵母细胞线粒体数量减少。线粒体是细胞的能量工厂，它们的缺乏可能导致受精率降低和胚胎发育不良。已经测试了各种策略来增加线粒体的数量，从而提高体外受精中使用的卵母细胞的质量。卵巢再生技术如自体线粒体移植的结果一直存在争议。在这篇综述中，我们描述了有关使用线粒体DNA和自体线粒体移植的最新技术，作为增加体外受精成功率的新可能性。