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Polycystic ovary syndrome and mitochondrial dysfunction.
Reproductive Biology and Endocrinology ( IF 4.2 ) Pub Date : 2019-08-16 , DOI: 10.1186/s12958-019-0509-4
Jingshun Zhang 1 , Yigang Bao 1 , Xu Zhou 2 , Lianwen Zheng 1
Affiliation  

Polycystic ovary syndrome (PCOS) is a prevalent hormonal disorder of premenopausal women worldwide and is characterized by reproductive, endocrine, and metabolic abnormalities. The clinical manifestations of PCOS include oligomenorrhea or amenorrhea, hyperandrogenism, ovarian polycystic changes, and infertility. Women with PCOS are at an increased risk of suffering from type 2 diabetes; me\tabolic syndrome; cardiovascular events, such as hypertension, dyslipidemia; gynecological diseases, including infertility, endometrial dysplasia, endometrial cancer, and ovarian malignant tumors; pregnancy complications, such as premature birth, low birthweight, and eclampsia; and emotional and mental disorders in the future. Although numerous studies have focused on PCOS, the underlying pathophysiological mechanisms of this disease remain unclear. Mitochondria play a key role in energy production, and mitochondrial dysfunction at the cellular level can affect systemic metabolic balance. The recent wide acceptance of functional mitochondrial disorders as a correlated factor of numerous diseases has led to the presupposition that abnormal mitochondrial metabolic markers are associated with PCOS. Studies conducted in the past few years have confirmed that increased oxidative stress is associated with the progression and related complications of PCOS and have proven the relationship between other mitochondrial dysfunctions and PCOS. Thus, this review aims to summarize and discuss previous and recent findings concerning the relationship between mitochondrial dysfunction and PCOS.

中文翻译:

多囊卵巢综合征和线粒体功能障碍。

多囊卵巢综合征(PCOS)是全世界绝经前女性的一种普遍的激素疾病,其特征是生殖,内分泌和代谢异常。PCOS的临床表现包括少月经或闭经,雄激素过多,卵巢多囊性改变和不育。患有PCOS的女性罹患2型糖尿病的风险增加;代谢综合征; 心血管事件,例如高血压,血脂异常;妇科疾病,包括不孕症,子宫内膜异型增生,子宫内膜癌和卵巢恶性肿瘤;妊娠并发症,如早产,低出生体重和子痫;以及将来的情绪和精神疾病。尽管许多研究集中在PCOS上,但该疾病的潜在病理生理机制仍不清楚。线粒体在能量产生中起关键作用,而细胞水平的线粒体功能障碍会影响全身代谢平衡。作为许多疾病的相关因素,功能性线粒体疾病最近得到了广泛的接受,这导致了异常的线粒体代谢标记物与PCOS相关的假设。过去几年进行的研究证实,氧化应激的增加与PCOS的进展和相关并发症有关,并证明了其他线粒体功能障碍与PCOS之间的关系。因此,本综述旨在总结和讨论关于线粒体功能障碍与PCOS之间关系的以前和最近的发现。细胞水平的线粒体功能障碍可能影响全身代谢平衡。作为许多疾病的相关因素,功能性线粒体疾病最近得到了广泛的接受,这导致了异常的线粒体代谢标记物与PCOS相关的假设。过去几年进行的研究证实,氧化应激的增加与PCOS的进展和相关并发症有关,并证明了其他线粒体功能障碍与PCOS之间的关系。因此,本综述旨在总结和讨论关于线粒体功能障碍与PCOS之间关系的以前和最近的发现。细胞水平的线粒体功能障碍可能影响全身代谢平衡。作为许多疾病的相关因素,功能性线粒体疾病最近得到了广泛的接受,这导致了异常的线粒体代谢标记物与PCOS相关的假设。过去几年进行的研究证实,氧化应激的增加与PCOS的进展和相关并发症有关,并证明了其他线粒体功能障碍与PCOS之间的关系。因此,本综述旨在总结和讨论关于线粒体功能障碍与PCOS之间关系的以前和最近的发现。作为许多疾病的相关因素,功能性线粒体疾病最近得到了广泛的接受,这导致了异常的线粒体代谢标记物与PCOS相关的假设。过去几年进行的研究证实,氧化应激的增加与PCOS的进展和相关并发症有关,并证明了其他线粒体功能障碍与PCOS之间的关系。因此,本综述旨在总结和讨论关于线粒体功能障碍与PCOS之间关系的以前和最近的发现。作为许多疾病的相关因素,功能性线粒体疾病最近得到了广泛的接受,这导致了异常的线粒体代谢标记物与PCOS相关的假设。过去几年进行的研究证实,氧化应激的增加与PCOS的进展和相关并发症有关,并证明了其他线粒体功能障碍与PCOS之间的关系。因此,本综述旨在总结和讨论关于线粒体功能障碍与PCOS之间关系的以前和最近的发现。过去几年进行的研究证实,氧化应激的增加与PCOS的进展和相关并发症有关,并证明了其他线粒体功能障碍与PCOS之间的关系。因此,本综述旨在总结和讨论关于线粒体功能障碍与PCOS之间关系的以前和最近的发现。过去几年进行的研究已经证实,氧化应激的增加与PCOS的进展和相关并发症有关,并证明了其他线粒体功能障碍与PCOS之间的关系。因此,本综述旨在总结和讨论关于线粒体功能障碍与PCOS之间关系的以前和最近的发现。
更新日期:2019-08-16
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