BACKGROUND Mediterranean diet (MediDiet) had been reported to be beneficial to human health. However the relationship between diet pattern and outcomes of in vitro fertilization (IVF) treatment was scarcely researched. This study was aimed to explore the correlation between MediDiet pattern of infertile women and their clinical outcomes of IVF cycles. METHODS An observational prospective cohort study was conducted in the reproductive center from September 2016 to December 2017. Seven hundred infertile women about to undergo IVF treatment were asked to conduct a questionnaire survey. Patients were assigned to higher MediDiet adherence group or lower MediDiet adherence group according to their Mediterranean diet scores. Laboratory parameters and clinical outcomes were compared and those were different between groups were further analyzed for their relationship with MediDiet adherence. RESULTS A total of 590 women were finally included in the study. According to MediDiet scores, 228 participants were categorized as higher MediDiet adherence group and 362 others as lower MediDiet adherence group. No significant differences were found in baseline characteristics between groups. Higher MediDiet adherence group showed larger number of embryos available (8.40 ± 5.26 vs 7.40 ± 4.71, P = 0.028). Clinical pregnancy rate and implantation rate were similar between the two groups. In further correlation tests and multivariate linear regression analysis, number of fertilized oocytes and embryo yield were positively correlated to MediDiet adherence of participants. CONCLUSION Infertile women with greater adherence to Mediterranean diet pattern were likely to obtain more embryos available in IVF cycle.

中文翻译：

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地中海饮食提高了试管婴儿的胚胎产量：一项前瞻性队列研究。

背景技术据报道，地中海饮食（MediDiet）对人体健康有益。然而，很少研究饮食模式与体外受精（IVF）治疗结果之间的关系。这项研究旨在探讨不育妇女的MediDiet模式与其体外受精周期临床结果之间的相关性。方法从2016年9月至2017年12月在生殖中心进行了一项观察性前瞻性队列研究。要求700名即将接受试管婴儿的不育妇女进行问卷调查。根据地中海饮食评分，将患者分为较高的MediDiet依从性组或较低的MediDiet依从性组。比较了实验室参数和临床结局，并进一步分析了各组之间的差异与它们与MediDiet依从性的关系。结果总共有590名妇女最终被纳入研究。根据MediDiet评分，将228名参与者分类为MediDiet依从性较高的组，将362名参与者分类为MediDiet较低的依从性组。两组之间的基线特征没有发现显着差异。较高的MediDiet依从性组显示可利用的胚胎数量更多（8.40±5.26对7.40±4.71，P = 0.028）。两组的临床妊娠率和着床率相似。在进一步的相关性测试和多元线性回归分析中，受精卵的数量和胚胎产量与参与者对MediDiet的依从性呈正相关。