BACKGROUND Mediterranean diet (MediDiet) had been reported to be beneficial to human health. However the relationship between diet pattern and outcomes of in vitro fertilization (IVF) treatment was scarcely researched. This study was aimed to explore the correlation between MediDiet pattern of infertile women and their clinical outcomes of IVF cycles. METHODS An observational prospective cohort study was conducted in the reproductive center from September 2016 to December 2017. Seven hundred infertile women about to undergo IVF treatment were asked to conduct a questionnaire survey. Patients were assigned to higher MediDiet adherence group or lower MediDiet adherence group according to their Mediterranean diet scores. Laboratory parameters and clinical outcomes were compared and those were different between groups were further analyzed for their relationship with MediDiet adherence. RESULTS A total of 590 women were finally included in the study. According to MediDiet scores, 228 participants were categorized as higher MediDiet adherence group and 362 others as lower MediDiet adherence group. No significant differences were found in baseline characteristics between groups. Higher MediDiet adherence group showed larger number of embryos available (8.40 ± 5.26 vs 7.40 ± 4.71, P = 0.028). Clinical pregnancy rate and implantation rate were similar between the two groups. In further correlation tests and multivariate linear regression analysis, number of fertilized oocytes and embryo yield were positively correlated to MediDiet adherence of participants. CONCLUSION Infertile women with greater adherence to Mediterranean diet pattern were likely to obtain more embryos available in IVF cycle.

中文翻译：

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地中海饮食可提高体外受精中的胚胎产量：一项前瞻性队列研究。


背景技术据报道地中海饮食(MediDiet)有益于人类健康。然而，饮食模式与体外受精（IVF）治疗结果之间的关系却很少被研究。本研究旨在探讨不孕女性的医疗饮食模式与其 IVF 周期临床结果之间的相关性。方法 2016年9月至2017年12月在生殖中心开展观察性前瞻性队列研究，对700名即将接受IVF治疗的不孕妇女进行问卷调查。根据地中海饮食评分，患者被分配到较高的医疗饮食依从性组或较低的医疗饮食依从性组。比较实验室参数和临床结果，并进一步分析组间差异与医疗饮食依从性的关系。结果 最终共有 590 名女性被纳入研究。根据 MediDiet 评分，228 名参与者被归类为较高 MediDiet 依从性组，另外 362 名参与者被归类为较低 MediDiet 依从性组。各组之间的基线特征没有发现显着差异。较高的 MediDiet 依从性组显示出更多的可用胚胎（8.40 ± 5.26 vs 7.40 ± 4.71，P = 0.028）。两组之间的临床妊娠率和着床率相似。在进一步的相关性测试和多元线性回归分析中，受精卵母细胞数量和胚胎产量与参与者的医疗饮食依从性呈正相关。结论 更坚持地中海饮食模式的不孕女性可能在 IVF 周期中获得更多可用胚胎。