Whether follicle-stimulating hormone receptor (FSHR) polymorphisms are implicated in premature ovarian insufficiency (POI) remains controversial. Thus, we performed this study to explore correlation between FSHR polymorphisms and POI in human beings. Literature retrieve was conducted in PubMed, Medline, Embase and CNKI. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Sixteen studies were enrolled for analyses. No significant relationship with POI was found for rs6165 and rs6166 polymorphisms in overall analyses. Further subgroup analyses revealed that rs6166 polymorphism was significantly associated with the risk of POI in Asians with both FEM and REM. Nevertheless, we failed to detect any significant associations with POI for other ethnicities. Our findings indicated that FSHR rs6166 polymorphism may serve as a potential genetic biomarker of POI in Asians, but not in other ethnicities.

中文翻译：

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的影响FSHR早产卵巢功能不全多态性在人类的Meta分析

促卵泡激素受体（FSHR）多态性是否与卵巢功能不全（POI）有关还存在争议。因此，我们进行了这项研究，以探索人类中FSHR多态性与POI之间的相关性。文献检索在PubMed，Medline，Embase和CNKI中进行。计算赔率（OR）和95％置信区间（CI）。纳入了16个研究进行分析。总体分析中未发现rs6165和rs6166多态性与POI显着相关。进一步的亚组分析显示，rs6166多态性与FEM和REM的亚洲人发生POI的风险显着相关。但是，我们未能发现其他种族与POI的任何重要关联。