BackgroundTo study the association of radiation risk in the 2nd –3rd generations with polymorphisms in the genes CYP1A1, CYP2E1, GSTP1 and changes in the thyroid.Methods5 polymorphic gene variants (rs1048943, rs4646421, rs2070676, rs3813867, rs1695) were studied in 399 people living in the East Kazakhstan region in this research. 248 people of the 2nd - 3rd generation lived in the territory with radiation exposure in Abai, Borodulikha areas, and 151 people the comparison group lived in Kurchum district without radiation exposure comparable in sex and age with control group.ResultsThe results show that there is a significant association of rs1048943 in exposed and unexposed groups (p < 0.003), and the absence of association of rs4646421, rs2070676, rs3813867, rs1695 in the studied groups. The mean value of thyroxine in carriers of the AG + GG genotype of rs4646421 is significantly lower than in AA genotype carriers (p = 0.04); no significant changes were found in genotypes’ distribution with thyroid-stimulating hormone and anti-thyroid peroxidase indicators. Significant changes were in levels of anti-thyroid peroxidase between exposed and unexposed groups (p = 0.007). The thyroxine - thyroid-stimulating hormone levels were not significantly different in exposed and unexposed groups (p > 0.3).ConclusionsThis study demonstrated the association of rs1048943 polymorphism with living in the radiation zone in the 2nd and 3rd generations for the first time. Thyroxine levels decrease was identified in the 2nd and 3rd generation residents of the exposed area, as well as a significant increase of anti-thyroid peroxidase occurs in individuals of the 2nd and 3rd generation living in areas with radiation exposure.

中文翻译：

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第二代和第三代辐射风险与CYP1A1、CYP2E1、GSTP1基因多态性和甲状腺变化的相关性

背景研究第2-3代辐射风险与CYP1A1、CYP2E1、GSTP1基因多态性和甲状腺变化的相关性。方法5多态性基因变异（rs1048943、rs4646421、rs2070676、rs38138695）在东哈萨克斯坦地区进行这项研究。2-3代248人居住在Abai、Borodulikha地区受辐射地区，对照组151人居住在Kurchum地区未受辐射影响与对照组在性别、年龄上具有可比性。 rs1048943 在暴露组和未暴露组中显着相关 (p < 0.003)，并且在研究组中没有 rs4646421、rs2070676、rs3813867、rs1695 的关联。rs4646421的AG+GG基因型携带者甲状腺素的平均值显着低于AA基因型携带者（p=0.04）；促甲状腺激素和抗甲状腺过氧化物酶指标的基因型分布未见明显变化。暴露组和未暴露组之间的抗甲状腺过氧化物酶水平有显着变化（p = 0.007）。暴露组和未暴露组的甲状腺素-促甲状腺激素水平无显着差异（p > 0.3）。结论本研究首次证明了rs1048943多态性与生活在辐射区2代和3代的相关性。暴露区域的第 2 代和第 3 代居民的甲状腺素水平下降，