BACKGROUND Impairments of functional mobility may affect locomotion and quality of life in subjects with Parkinson's disease (PD). Movement smoothness measurements, such as the spectral arc length (SPARC), are novel approaches to quantify movement quality. Previous studies analyzed SPARC in simple walking conditions. However, SPARC outcomes during functional mobility tasks in subjects with PD and freezing of gait (FOG) were never investigated. This study aimed to analyze SPARC during the Timed Up and Go (TUG) test in individuals with PD and FOG. METHODS Thirty-one participants with PD and FOG and six healthy controls were included. SPARC during TUG test was calculated for linear and angular accelerations using an inertial measurement unit system. SPARC data were correlated with clinical parameters: motor section of the Unified Parkinson's Disease Rating Scale, Hoehn & Yahr scale, Freezing of Gait Questionnaire, and TUG test. RESULTS We reported lower SPARC values (reduced smoothness) during the entire TUG test, turn and stand to sit in subjects with PD and FOG, compared to healthy controls. Unlike healthy controls, individuals with PD and FOG displayed a broad spectral range that encompassed several dominant frequencies. SPARC metrics also correlated with all the above-mentioned clinical parameters. CONCLUSION SPARC values provide valid and relevant clinical data about movement quality (e.g., smoothness) of subjects with PD and FOG during a functional mobility test.

中文翻译：

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在患有帕金森氏病和步态冻结的受试者进行功能性机动性任务期间的运动平滑度-使用惯性测量单位进行的分析。

背景技术功能性活动障碍可影响患有帕金森氏病（PD）的受试者的运动和生活质量。运动平滑度测量（例如光谱弧长（SPARC））是量化运动质量的新颖方法。先前的研究在简单的步行条件下分析了SPARC。然而，从未研究过PD和步态冻结（FOG）受试者在功能移动任务期间的SPARC结果。这项研究的目的是在PD和FOG个体中的Timed Up and Go（TUG）测试期间分析SPARC。方法包括PD和FOG的31名参与者和6名健康对照者。使用惯性测量单位系统计算TUG测试期间的SPARC的线性和角加速度。SPARC数据与临床参数相关：Unified Parkinson's运动部分 疾病等级量表，Hoehn＆Yahr量表，步态冻结问卷和TUG测试。结果我们报告说，与健康对照组相比，在整个TUG测试，PD和FOG受试者转身站立时，SPARC值降低（平滑度降低）。与健康对照组不同，PD和FOG个体显示出宽广的光谱范围，涵盖了几个主要频率。SPARC指标还与所有上述临床参数相关。结论SPARC值提供了有关功能性活动性测试期间PD和FOG患者的运动质量（例如，光滑度）的有效且相关的临床数据。与健康对照组相比，转身站立以PD和FOG为对象。与健康对照组不同，PD和FOG个体显示出宽广的光谱范围，涵盖了几个主要频率。SPARC指标还与所有上述临床参数相关。结论SPARC值提供了有关功能性活动性测试中PD和FOG患者的运动质量（例如，光滑度）的有效且相关的临床数据。与健康对照组相比，转身站立以PD和FOG为对象。与健康对照组不同，PD和FOG个体显示出宽广的光谱范围，涵盖了几个主要频率。SPARC指标还与所有上述临床参数相关。结论SPARC值提供了有关功能性活动性测试中PD和FOG患者的运动质量（例如，光滑度）的有效且相关的临床数据。