Epilepsy affects 2.2 million adults in the USA, with 1 in 26 people developing epilepsy at some point in their lives. Temporal lobe epilepsy (TLE) is the most common form of focal epilepsy as medial structures, and the hippocampus in particular, are prone to generating seizures. Selective anterior temporal resection (which removes the hippocampus) is the most effective intractable TLE treatment, but given the critical role of the mesial temporal lobe in memory functioning, resection can have negative effects on this crucial cognitive skill. To minimize the adverse impact of temporal lobe surgery on memory functioning, reliable pre-surgical guides are needed. Clinical functional magnetic resonance imaging (fMRI) provides reliable, noninvasive guidance of language functioning and plays a growing role in the pre-surgical evaluation for epilepsy patients; however, localization of memory function in children with epilepsy using fMRI has not been established. Aside from the lack of neuroimaging memory studies in children with TLE, studies of typical development are limited. This review will focus on the functional anatomy of memory systems throughout development, with a focus on TLE. TLE provides the ideal model from which to understand memory function and the limits of plasticity and compensation/reorganization throughout development.

中文翻译：

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在发育过程中和儿童癫痫发作期间对情景记忆进行成像。

在美国，癫痫病影响了220万成年人，其中每26人中就有1人在生活中的某个阶段发展为癫痫病。颞叶癫痫（TLE）是局灶性癫痫的最常见形式，因为其内侧结构，尤其是海马体容易发生癫痫发作。选择性前颞叶切除术（去除海马体）是最有效的顽固性TLE治疗，但考虑到颞叶颞叶在记忆功能中的关键作用，切除术可能会对这一关键的认知技能产生负面影响。为了最大程度地减少颞叶手术对记忆功能的不利影响，需要可靠的手术前指南。临床功能磁共振成像（fMRI）可提供可靠的，语言功能的非侵入性指导，在癫痫患者的术前评估中起着越来越重要的作用；然而，尚未确定使用功能磁共振成像对癫痫患儿的记忆功能进行定位。除了缺乏对TLE儿童的神经影像记忆研究以外，对典型发育的研究还很有限。本文将重点关注整个开发过程中内存系统的功能解剖，重点是TLE。TLE提供了理想的模型，从中可以了解内存功能以及整个开发过程中可塑性和补偿/重组的限制。本文将重点关注整个开发过程中内存系统的功能解剖，重点是TLE。TLE提供了理想的模型，从中可以了解内存功能以及整个开发过程中可塑性和补偿/重组的限制。本文将重点关注整个开发过程中内存系统的功能解剖，重点是TLE。TLE提供了理想的模型，从中可以了解内存功能以及整个开发过程中可塑性和补偿/重组的限制。