The construction of a multifunctional drug delivery system with a variety of advantageous features, including targeted delivery, controlled release and combined therapy, is highly attractive but remains a challenge. In this study, we developed a MoS2-based hyaluronic acid (HA)-functionalized nanoplatform capable of achieving targeted delivery of camptothecin (CPT) and dual-stimuli-responsive drug release. HA was connected to MoS2 via a disulfide linkage, forming a sheddable HA shell on the surface of MoS2. This unique design not only effectively prevented the encapsulated CPT from randomly leaking during blood circulation but also significantly accelerated the drug release in response to tumor-associated glutathione (GSH). Moreover, the MoS2-based generated heat upon near-infrared (NIR) irradiation could further increase the drug release rate as well as induce photothermal ablation of cancer cells. The results of in vitro and in vivo experiments revealed that MoS2–SS–HA–CPT effectively suppressed cell proliferation and inhibited tumor growth in lung cancer cell-bearing mice under NIR irradiation via synergetic chemo-photothermal therapy. The as-prepared MoS2–SS–HA–CPT with high targeting ability, dual-stimuli-responsive drug release, and synergistic chemo-photothermal therapy may provide a new strategy for cancer therapy.

中文翻译：

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氧化还原/近红外双响应MoS ₂用于癌症的协同化学光热疗法

具有包括靶向递送，控释和联合疗法在内的多种有利特征的多功能药物递送系统的构建是非常有吸引力的，但是仍然是一个挑战。在这项研究中，我们开发了基于MoS2的透明质酸（HA）功能化的纳米平台，能够实现喜树碱（CPT）的靶向递送和双重刺激反应性药物释放。HA通过二硫键连接到MoS2，在MoS2的表面形成可脱落的HA壳。这种独特的设计不仅有效地防止了封装的CPT在血液循环中随机泄漏，而且还显着加速了药物对肿瘤相关谷胱甘肽（GSH）的释放。而且，基于MoS2的近红外（NIR）辐射产生的热量可以进一步提高药物释放速率以及诱导癌细胞的光热消融。体外和体内实验的结果表明，MoS2-SS-HA-CPT通过协同化学光热疗法在NIR照射下能有效抑制荷瘤小鼠的细胞增殖并抑制肿瘤生长。制备的具有高靶向能力，双重刺激反应性药物释放和协同化学光热疗法的MoS2-SS-HA-CPT可能为癌症治疗提供新的策略。体外和体内实验的结果表明，MoS2-SS-HA-CPT通过协同化学光热疗法在NIR照射下能有效抑制荷瘤小鼠的细胞增殖并抑制肿瘤生长。制备的具有高靶向能力，双重刺激反应性药物释放和协同化学光热疗法的MoS2-SS-HA-CPT可能为癌症治疗提供新的策略。体外和体内实验的结果表明，MoS2-SS-HA-CPT通过协同化学光热疗法在NIR照射下能有效抑制荷瘤小鼠的细胞增殖并抑制肿瘤生长。制备的具有高靶向能力，双重刺激反应性药物释放和协同化学光热疗法的MoS2-SS-HA-CPT可能为癌症治疗提供新的策略。