The gastric cancer is the second most malignant tumor in the world. HER-2 is one of the key targets for the gastric cancer therapy. Anti-HER-2 antibodies like trastuzumab, exhibits the satisfactory therapeutic effect in clinical. However, the drug resistance problem limits its application. In this study, we develop a gold nanoshell (Gold Nanoshell) drug carrier for delivery and selective photo-thermal release of genes which target HER-2 and immunologic adjuvant CPG sequence in gastric tumor cells. The drug delivery system generated a multidimensional treatment strategy which includes gene-, immune- and photothermal-therapy. The whole gold nanoshell drug delivery system exhibits the well gene transduction ability and combined treatment effect. Both in vitro and in vivo results demonstrate the multiple therapeutic effects of the drug delivery system is better than the monotherapy. This study indicates the multiple combined therapy based on the gold nanoshell system would be a promising translational treatment for gastric cancer.

中文翻译：

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基于金纳米壳的系统光热和基因治疗联合免疫治疗胃癌


胃癌是世界上第二大恶性肿瘤。 HER-2是胃癌治疗的关键靶点之一。抗HER-2抗体如曲妥珠单抗，在临床上表现出令人满意的治疗效果。但耐药性问题限制了其应用。在这项研究中，我们开发了一种金纳米壳（Gold Nanoshell）药物载体，用于在胃肿瘤细胞中递送和选择性光热释放靶向HER-2和免疫佐剂CPG序列的基因。该药物输送系统产生了多维治疗策略，包括基因疗法、免疫疗法和光热疗法。整个金纳米壳药物递送系统表现出良好的基因转导能力和综合治疗效果。体外和体内结果均表明该药物递送系统的多重治疗效果优于单一疗法。这项研究表明基于金纳米壳系统的多重联合疗法将是一种有前途的胃癌转化治疗方法。