Myeloid-derived suppressor cells (MDSCs) are newly identified immature myeloid cells that are characterized by the ability to suppress immune responses and expand during cancer, infection, and inflammatory diseases. Although MDSCs have attracted a lot of attention in the field of tumor immunology in recent years, little is known about their multiple roles in hematological malignancies as opposed to their roles in solid tumors. This review will help researchers better understand the various characteristics and functions of MDSCs, as well as the potential therapeutic applications of MDSCs in hematological malignancies, including lymphoma, multiple myeloma, leukemia, and hematopoietic stem cell transplantation.

中文翻译：

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血液系统恶性肿瘤中髓样来源的抑制细胞：朋友还是敌人。

髓样来源的抑制细胞（MDSC）是新近鉴定出的未成熟髓样细胞，其特征在于具有抑制免疫反应并在癌症，感染和炎症性疾病中扩展的能力。尽管近年来MDSC已经在肿瘤免疫学领域引起了很多关注，但是关于它们在血液系统恶性肿瘤中的多重作用而不是它们在实体瘤中的作用知之甚少。这篇综述将帮助研究人员更好地了解MDSC的各种特征和功能，以及MDSC在血液系统恶性肿瘤（包括淋巴瘤，多发性骨髓瘤，白血病和造血干细胞移植）中的潜在治疗应用。