N6-methyladenosine (m6A) methylation, one of the most common RNA modifications, has been reported to execute important functions that affect normal life activities and diseases. Most studies have suggested that m6A modification can affect the complexity of cancer progression by regulating biological functions related to cancer. M6A modification of noncoding RNAs regulates the cleavage, transport, stability, and degradation of noncoding RNAs themselves. It also regulates cell proliferation and metastasis, stem cell differentiation, and homeostasis in cancer by affecting the biological function of cells. Interestingly, noncoding RNAs also play significant roles in regulating these m6A modifications. Additionally, it is becoming increasingly clear that m6A and noncoding RNAs potentially contribute to the clinical application of cancer treatment. In this review, we summarize the effect of the interactions between m6A modifications and noncoding RNAs on the biological functions involved in cancer progression. In particular, we discuss the role of m6A and noncoding RNAs as possible potential biomarkers and therapeutic targets in the treatment of cancers.

中文翻译：

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癌症中 m6A RNA 甲基化和非编码 RNA 之间的相互作用。

N6-甲基腺苷 (m6A) 甲基化是最常见的 RNA 修饰之一，据报道执行影响正常生命活动和疾病的重要功能。大多数研究表明，m6A 修饰可以通过调节与癌症相关的生物学功能来影响癌症进展的复杂性。非编码 RNA 的 M6A 修饰调节非编码 RNA 本身的切割、运输、稳定性和降解。它还通过影响细胞的生物学功能来调节癌症中的细胞增殖和转移、干细胞分化和体内平衡。有趣的是，非编码 RNA 在调节这些 m6A 修饰方面也发挥着重要作用。此外，越来越清楚的是，m6A 和非编码 RNA 可能有助于癌症治疗的临床应用。在这篇综述中，我们总结了 m6A 修饰和非编码 RNA 之间的相互作用对参与癌症进展的生物学功能的影响。特别是，我们讨论了 m6A 和非编码 RNA 作为可能的潜在生物标志物和治疗靶点在癌症治疗中的作用。