BACKGROUND The importance of discriminating acute from non-acute thrombus is highlighted. The study aims to investigate the feasibility of readout-segmented diffusion weighted (DW) cardiovascular magnetic resonance (CMR) for discrimination of acute from non-acute deep venous thrombus (DVT). METHODS For this prospective study from December 2015 to December 2017, 85 participants (mean age = 53 years, age range = 34~74) with DVT of lower extremities underwent readout-segmented DW CMR. DVT of ≤14 days were defined as acute (n = 55) and > 14 days as non-acute (n = 30). DVT visualization on b = 0, b = 800, and apparent diffusion coefficient (ADC) images were assessed using a 4-point scale (0~3, poor~excellent). DW CMR parameters were measured using region of interest (ROI). Relative signal intensity (rSI) and ADC were compared between acute and non-acute DVT using a Mann Whitney test. Sensitivity and specificity for ADC and rSI were calculated. RESULTS ADC maps had higher visualization scores than b = 0 and b = 800 images (2.7 ± 0.5, 2.5 ± 0.6, and 2.4 ± 0.6 respectively, P<0.05). The mean ADC was higher in acute DVT than non-acute DVT (0.56 ± 0.17 × 10- 3 vs. 0.22 ± 0.12 × 10- 3 mm2/s, P<0.001). Using 0.32 × 10- 3 mm2/s as the cutoff, sensitivity and specificity for ADC to discriminate acute from non-acute DVT were 93 and 90% respectively. Sensitivity and specificity were 73 and 60% for rSI on b = 0, and 75 and 63% for rSI on b = 800. CONCLUSIONS Readout segmented diffusion-weighted CMR derived ADC distinguishes acute from non-acute DVT. TRIAL REGISTRATION This study is retrospectively registered. TRIAL REGISTRATION NUMBER HUST-TJH-2015-146 .

中文翻译：

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扩散加权心血管磁共振成像用于区分急性和非急性深静脉血栓。


背景技术强调了区分急性和非急性血栓的重要性。该研究旨在探讨读出分段扩散加权（DW）心血管磁共振（CMR）区分急性和非急性深静脉血栓（DVT）的可行性。方法 在2015年12月至2017年12月的这项前瞻性研究中，85名下肢DVT参与者（平均年龄= 53岁，年龄范围= 34~74岁）接受了读出分段DW CMR。 DVT ≤ 14 天被定义为急性 (n = 55)，> 14 天被定义为非急性 (n = 30)。 b = 0、b = 800 上的 DVT 可视化和表观扩散系数 (ADC) 图像使用 4 分制（0~3、差~优秀）进行评估。 DW CMR 参数使用感兴趣区域 (ROI) 进行测量。使用 Mann Whitney 测试比较急性和非急性 DVT 的相对信号强度 (rSI) 和 ADC。计算 ADC 和 rSI 的敏感性和特异性。结果 ADC 图比 b = 0 和 b = 800 图像具有更高的可视化分数（分别为 2.7 ± 0.5、2.5 ± 0.6 和 2.4 ± 0.6，P<0.05）。急性 DVT 的平均 ADC 高于非急性 DVT（0.56 ± 0.17 × 10- 3 vs. 0.22 ± 0.12 × 10- 3 mm2/s，P<0.001）。使用 0.32 × 10- 3 mm2/s 作为截止值，ADC 区分急性和非急性 DVT 的敏感性和特异性分别为 93% 和 90%。 b = 0 时 rSI 的敏感性和特异性分别为 73% 和 60%，b = 800 时 rSI 的敏感性和特异性分别为 75% 和 63%。 结论 读出分段扩散加权 CMR 衍生的 ADC 可区分急性和非急性 DVT。试验注册 本研究是回顾性注册的。试用注册号 HUST-TJH-2015-146 。