BACKGROUND Cine fast interrupted steady-state in combination with arterial spin labeling is a recently described nonenhanced magnetic resonance angiography (MRA) technique that relies on bolus tracking for time-resolved digital subtraction angiography-like displays of blood flow patterns. We evaluated the feasibility of applying this technique to display in-plane flow patterns in two regions: the abdominal aorta and lower extremity peripheral arteries. METHODS We performed an institutional review board-approved study in healthy subjects and patients. In 7 healthy subjects, in-plane flow was imaged at 4 stations ranging from the lower legs to the aorto-iliac bifurcation (junction of the distal thigh and upper calf, mid-thigh, junction of the upper thigh and pelvis, upper pelvis). In 5 healthy subjects and 6 patients without abdominal aortopathy, images were acquired through the suprarenal abdominal aorta. Ten patients with known peripheral arterial disease and two patients with stable disease of the abdominal aorta were also evaluated. Peak velocity was compared at each of the 4 stations for cine fast interrupted steady-state in combination with arterial spin labeling and two-dimensional cine phase contrast in patients with normal vessels. RESULTS In-plane flow patterns were well visualized in all peripheral arterial stations and in the abdominal aorta, providing a high quality display of hemodynamic patterns along extensive lengths of the vessels. There was very strong positive correlation (r = 0.952, P < 0.05) and excellent agreement (intraclass correlation coefficient, 0.935; 95% confidence interval, 0.812-0.972) between peak flow velocities measured by cine fast interrupted steady-state in combination with arterial spin labeling and two-dimensional cine phase contrast. In 10 patients with peripheral artery disease and 2 patients with aortic pathology, cine fast interrupted steady-state in combination with arterial spin labeling provided a visual demonstration of abnormal hemodynamics. CONCLUSION This feasibility study suggests that cine fast interrupted steady-state in combination with arterial spin labeling provides an efficient, high quality and physiologically accurate display of in-plane flow patterns over extensive lengths of the lower extremity peripheral arteries, which can be difficult to achieve using other MRA techniques.

中文翻译：

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使用电影快速中断稳态结合动脉自旋标记对腹主动脉和下肢进行动态定量非增强磁共振血管造影：可行性研究。


背景技术电影快速中断稳态与动脉自旋标记相结合是最近描述的非增强磁共振血管造影(MRA)技术，其依赖于团注跟踪来进行类似于时间分辨数字减影血管造影的血流模式显示。我们评估了应用该技术显示两个区域的平面内血流模式的可行性：腹主动脉和下肢外周动脉。方法 我们对健康受试者和患者进行了机构审查委员会批准的研究。在 7 名健康受试者中，在从小腿到主髂动脉分叉处（大腿远端和小腿上部的交界处、大腿中部、大腿上部和骨盆的交界处、上骨盆）的 4 个站点进行了平面内血流成像。在 5 名健康受试者和 6 名无腹主动脉病的患者中，通过肾上腹主动脉获取图像。还对十名已知外周动脉疾病的患者和两名腹主动脉疾病稳定的患者进行了评估。在具有正常血管的患者中，结合动脉自旋标记和二维电影相位对比，比较了 4 个站中每个站的峰值速度，以进行电影快速中断稳态。结果 所有外周动脉站和腹主动脉的平面内血流模式都清晰可见，提供了沿血管广泛长度的血流动力学模式的高质量显示。存在非常强的正相关性（r = 0.952，P < 0.05）和极好的一致性（组内相关系数，0.935；95% 置信区间，0.812-0）。972）通过电影快速中断稳态结合动脉自旋标记和二维电影相位对比测量的峰值流速之间。在 10 名外周动脉疾病患者和 2 名主动脉病变患者中，电影快速中断稳态与动脉自旋标记相结合，提供了异常血流动力学的视觉演示。结论 这项可行性研究表明，电影快速中断稳态与动脉自旋标记相结合，可以有效、高质量和生理学准确地显示下肢外周动脉大范围内的平面内血流模式，而这可能很难实现使用其他 MRA 技术。