Abdominal obesity is an independent risk factor for coronary heart disease (CHD) and high serum triglyceride (TG) and free fatty acid levels may precipitate or aggravate CHD. We enrolled patients with coronary heart disease in our hospital from October 2008 to July 2009. Patients with high TG and increased WC, i.e. waist phenotype WP were included in group A. In group B, were included patients with high TG but not WP. Group C consisted of patients with WP but not high TG. Finally, Group D was composed of patients without high TG or WP. Serum FFA levels for all patients were measured by ELISA. The relationship between TG levels, WC, FFA levels, and coronary artery score was analysed by a single variable regression. Group A had a significantly higher FFA level than the other groups. Regression analysis showed that FFA, TG, WC, hip circumference, waist-to-height ratio, systolic blood pressure, pulse pressure index, and low-density lipoprotein cholesterol all positively correlated with CAS (r = 0.160 ~ 0.415, P = 0.000 ~ 0.032). After we controlled for traditional risk factors for cardiovascular disease, FFA levels remained positively correlated to the CAS (r = 0.365, P < 0.001). The serum FFA level for patients with complications of both increased WC and high TG levels was significantly higher than that of patients without either of these complications. The close correlation between the CAS and FFA levels showed by regression analysis suggested that inflammation in these patients was more serious. Increased WC and high TG levels as well as FFA level are valuable for the prediction of cardiovascular disease and can be applied as a clinical guidance for early intervention in the treatment of coronary heart diseases.

中文翻译：

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成人及老年冠心病患者腰部表型、高甘油三酯血症、冠状动脉病变与血清游离脂肪酸的关系研究

腹型肥胖是冠心病（CHD）的独立危险因素，高血清甘油三酯（TG）和游离脂肪酸水平可能导致或加重冠心病。我们于2008年10月至2009年7月在我院招募了冠心病患者。A组包括高TG和WC增加的患者，即腰部WP表型。B组包括高TG但不包括WP的患者。C 组由 WP 但不高 TG 的患者组成。最后，D 组由没有高 TG 或 WP 的患者组成。通过ELISA测量所有患者的血清FFA水平。通过单变量回归分析TG水平、WC、FFA水平和冠状动脉评分之间的关​​系。A组的FFA水平显着高于其他组。回归分析显示，FFA、TG、WC、臀围、腰高比、收缩压、脉压指数、低密度脂蛋白胆固醇均与CAS呈正相关（r=0.160～0.415，P=0.000～0.032）。在我们控制了心血管疾病的传统危险因素后，FFA 水平仍与 CAS 呈正相关（r = 0.365，P < 0.001）。有 WC 升高和 TG 水平升高的并发症患者的血清 FFA 水平显着高于没有这两种并发症的患者。回归分析显示 CAS 和 FFA 水平密切相关，表明这些患者的炎症更为严重。