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Healthy elderly Singaporeans show no age-related humoral hyporesponsiveness nor diminished plasmablast generation in response to influenza vaccine
Immunity & Ageing ( IF 5.2 ) Pub Date : 2018-11-12 , DOI: 10.1186/s12979-018-0137-4
Xavier Camous 1 , Lucian Visan 2 , Crystal Tan Tze Ying 1 , Brian Abel 3 , Ma Shwe Zin Nyunt 4 , Vipin Narang 3 , Michael Poidinger 3 , Christophe Carre 2 , Sanie Sesay 5 , Nabil Bosco 6 , Nicolas Burdin 2 , Paul Anantharajah Tambyah 7 , Ng Tze Pin 4 , Anis Larbi 1, 3
Affiliation  

Improving influenza vaccine efficacy is a priority to reduce the burden of influenza-associated morbidity and mortality. By careful selection of individuals based on health we show sustained response to influenza vaccination in older adults. Sustaining health in aging could be an important player in maintaining immune responses to influenza vaccination. NCT03266237. Registered 30 August 2017, https://clinicaltrials.gov/ct2/show/NCT03266237 .

中文翻译:

健康的新加坡老年人对流感疫苗的反应没有表现出与年龄相关的体液低反应性,也没有减少浆母细胞的产生

提高流感疫苗的效力是减少流感相关发病率和死亡率负担的优先事项。通过根据健康状况仔细选择个体,我们显示出老年人对流感疫苗接种的持续反应。在衰老过程中保持健康可能是维持对流感疫苗接种的免疫反应的重要因素。NCT03266237。2017 年 8 月 30 日注册,https://clinicaltrials.gov/ct2/show/NCT03266237。
更新日期:2020-04-22
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