Some components of Nutraceuticals (NUT) such as red yeast rice and Morus alba have demonstrated positive effects on the endothelial function in hypercholesterolemic subjects. Our aim was to compare the effects of two different NUT combinations on cold pressure test (CPT) derived coronary flow reserve (CFR) assessed by transthoracic echo-Doppler. In a randomized, single-blind study, 28 consecutive patients with a variety of cardiovascular risk factors received NUT A (LopiGLIK®: berberine, red yeast rice powder, and leaf extract of Morus alba) or B (Armolipid Plus®: policosanol, red yeast rice, berberine, astaxantine, folic acidandcoenzyme Q10). An echo-Doppler exam with evaluation of CFR was performed at baseline, 2 h (acute test) and 30 days after daily NUT assumption. Blood sampling for metabolic profile and platelet aggregometry was performed at baseline and after 30 days of daily NUT assumption. CFR was not significantly modified at the acute test. After 30 days, CFR improved with NUT A (p < 0.0001), because of the increase of hyperemic flow velocity (p = 0.007), but not with NUT B. CFR was comparable between the two groups at baseline but became significantly higher after 30 days in NUT A (p < 0.02), with a higher CFR percent variation versus baseline (p = 0.008). Total cholesterol and LDL-cholesterol were reduced with both NUT A (p < 0.001 and p < 0.002, respectively) and B (both p < 0.02), whereas platelet aggregation did not significantly change. In the pooled group of patients, after adjusting for age and percent changes of systolic blood pressure, heart rate, LDL-cholesterol and glycemia, NUT A – but not NUT B - was independently associated with CFR changes (β = 0.599, p = 0.003). LopiGLIK® improved endothelial-derived CFR, independently of the beneficial effects exerted on the lipid profile. These findings can have clinical reflections on the prevention of age-related inflammatory diseases including coronary artery disease. (NUTRENDO)″(ClinicalTrials.gov, NCT02969070 ).

中文翻译：

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营养组合对内皮介导的冠状动脉血流储备的不同年龄依赖性影响

Nutraceuticals (NUT) 的某些成分，如红曲米和桑白皮，已证明对高胆固醇血症受试者的内皮功能有积极作用。我们的目的是比较两种不同 NUT 组合对经胸超声多普勒评估的冷压试验 (CPT) 衍生的冠状动脉血流储备 (CFR) 的影响。在一项随机、单盲研究中，28 名患有多种心血管危险因素的连续患者接受了 NUT A（LopiGLIK®：黄连素、红曲米粉和桑叶提取物）或 B（Armolipid Plus®：多二十烷醇、红酵母米、黄连素、虾青素、叶酸和辅酶 Q10）。在基线、每日 NUT 假设后 2 小时（急性测试）和 30 天进行了评估 CFR 的回声多普勒检查。在基线和每日 NUT 假设 30 天后进行血样用于代谢特征和血小板聚集度测定。CFR 在急性试验中没有显着改变。30 天后，NUT A 的 CFR 得到改善（p < 0.0001），因为充血流速增加（p = 0.007），但 NUT B 没有。基线时两组的 CFR 相当，但在 30 天后显着升高NUT A 天数 (p < 0.02)，与基线相比具有更高的 CFR 百分比变化 (p = 0.008)。NUT A（分别为 p < 0.001 和 p < 0.002）和 B（均 p < 0.02）均降低了总胆固醇和 LDL-胆固醇，而血小板聚集没有显着变化。在合并的患者组中，在调整了年龄和收缩压、心率、低密度脂蛋白胆固醇和血糖的百分比变化后，NUT A - 但不是 NUT B - 与病死率变化独立相关 (β = 0.599, p = 0.003)。LopiGLIK® 改善了内皮衍生的 CFR，与对脂质谱的有益作用无关。这些发现可以对预防与年龄相关的炎症性疾病（包括冠状动脉疾病）有临床意义。（NUTRENDO）”（ClinicalTrials.gov，NCT02969070）。