Application of biological age assessment of Chinese population in potential anti-ageing technology,Immunity & Ageing

当前位置： X-MOL 学术 › Immun. Ageing › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Application of biological age assessment of Chinese population in potential anti-ageing technology
Immunity & Ageing ( IF 7.9 ) Pub Date : 2018-12-18 , DOI: 10.1186/s12979-018-0140-9
Xufeng Li ₁ , Jiren Zhang ₂ , Chen Sun ₂ , Yuanyuan Zhang ₂ , Rui Cai ₂ , Shilin Fu ₂ , Jingfen Zheng ₂ , Dehai Huang ₁

Affiliation

This study aimed to construct a biological age assessment formula for the Chinese population and to explore the effectiveness of double filtration plasmapheresis for anti-ageing and longevity. 915 subjects were recruited, including 584 (63.8%) males and 331 females (36.2%). Male age was 50.94±10.60 (mean±SD), and female age was 51.20±11.84 (mean±SD). 34 blood markers were detected in the laboratory. The ageing biomarkers were determined by statistical correlation analysis and redundancy analysis, and the biological age assessment formula was established by multiple linear regression analysis. Paired sample T test was used to analyse the elimination effect of double filtration plasmapheresis on aging biomarkers. Based on the comprehensive blood test and analysis, the ageing biomarkers were screened, and the male and female biological age assessment formulas were established. Then, the elimination of ageing biomarkers by double filtration plasmapheresis was examined. Double filtration plasmapheresis can eliminate ageing biomarkers, with an average of 4.47 years decrease in age for males and 8.36 years for females. So, biological age provides a scientific tool for assessing ageing, and double filtration plasmapheresis is safe and might be effective for anti-ageing and longevity. However, the effect of plasmapheresis is expected to be transient, so further studies are needed to plan the number and range of the plasmapheresis procedures necessary to consistently lower the parameters under study.

更新日期：2020-04-22

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南

全部期刊列表>>