Health-related quality of life and glycaemic control are some of the central outcomes in clinical diabetes care and research. The purpose of this study was to describe the health-related quality of life and assess its association with glycaemic control in adults with type 1 and type 2 diabetes in a nationwide setting. In this cross-sectional survey, people with type 1 (n = 2479) and type 2 diabetes (n = 2469) were selected at random without replacement from the Swedish National Diabetes Register. Eligibility criteria were being aged 18–80 years with at least one registered test of glycated haemoglobin (HbA1c) the last 12 months. The generic 36-item Short Form version 2 (SF-36v2) was answered by 1373 (55.4%) people with type 1 diabetes and 1353 (54.8%) with type 2 diabetes. Correlation analyses showed weak correlations between scores on the SF-36v2 and glycaemic control for both diabetes types. After the participants were divided into three groups based on their levels of HbA1c, multivariate regression analyses adjusted for demographics, other risk factors and diabetes complications showed that among participants with type 1 diabetes, the high-risk group (≥70 mmol/mol/8.6%) had statistically significantly lower means in five out of eight domains of the SF-36v2 and the mental component summary measure, as compared with the well-controlled group (< 52 mmol/mol/6.9%). Among the participants with type 2 diabetes, the high-risk group had the lowest statistically significantly means in seven domains and both summary measures. Among people with type 1 and type 2 diabetes, adults with high-risk HbA1c levels have lower levels of health-related quality of life in most but not all domains of the SF-36v2. This finding was not explained by demographics, other risk factors, or diabetes complications. The weak individual-level correlations between HRQOL scores and levels of glycaemic control argues for the need to not focus exclusively on either HbA1c levels or HRQOL scores but rather on both because both are important parts of a complex, life-long, challenging condition.

中文翻译：

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1型和2型糖尿病成年人的健康相关生活质量和血糖控制–一项全国性的横断面研究

与健康相关的生活质量和血糖控制是临床糖尿病护理和研究的一些主要成果。这项研究的目的是描述与健康相关的生活质量，并评估其与全国范围内成人1型和2型糖尿病患者的血糖控制的相关性。在这项横断面调查中，从瑞典国家糖尿病登记册中随机抽取了1型（n = 2479）和2型糖尿病（n = 2469）的患者。资格标准年龄为18-80岁，最近12个月至少进行了一项糖化血红蛋白（HbA1c）注册测试。1373型糖尿病的1373名患者和2型糖尿病的1353名（54.8％）患者回答了通用的36项简短版本2（SF-36v2）。相关分析表明，两种糖尿病的SF-36v2评分与血糖控制之间的相关性较弱。根据参与者的HbA1c水平将其分为三组后，针对人口统计学，其他风险因素和糖尿病并发症进行了多因素回归分析，结果显示，在1型糖尿病参与者中，高风险组（≥70mmol / mol / 8.6与正常对照组（<52 mmol / mol / 6.9％）相比，在SF-36v2和精神成分汇总量度的八个域中，五个域的统计学均值显着降低。在患有2型糖尿病的参与者中，高风险组的统计学意义均值在七个领域中最低，并且均为汇总指标。在1型和2型糖尿病患者中，HbA1c水平高风险的成年人在SF-36v2的大多数区域（但不是所有区域）中具有与健康相关的生活质量较低的水平。人口统计学，其他风险因素或糖尿病并发症并未解释这一发现。HRQOL评分与血糖控制水平之间的个体水平相关性较弱，这表明我们不仅需要专注于HbA1c水平或HRQOL评分，而不能同时关注两者，因为两者都是复杂，终生且具有挑战性的疾病的重要组成部分。