Previous studies show that escalations in ambient temperature are among the risk factors for acute kidney injury (AKI). However, it has not been adequately studied in our location, Seoul, South Korea. In this study, we aimed to examine the association between ambient temperatures and AKI morbidity using emergency department (ED) visit data. We obtained data on ED visits from the National Emergency Medical Center for 21,656 reported cases of AKI from 2010 to 2014. Time-stratified case-crossover design analysis based on conditional logistic regression was used to analyze short-term effects of ambient temperature on AKI after controlling for relevant covariates. The shape of the exposure–response curve, effect modification by individual demographic characteristics, season, and comorbidities, as well as lag effects, were investigated. The odds ratio (OR) per 1 °C increase at lag 0 was 1.0087 (95% confidence interval [CI]: 1.0041–1.0134). Risks were higher during the warm season (OR = 1.0149; 95% CI: 1.0065–1.0234) than during the cool season (OR = 1.0059; 95% CI: 1.0003–1.0116) and even higher above 22.3 °C (OR = 1.0235; 95% CI: 1.0230–1.0239). This study provides evidence that ED visits for AKI were associated with ambient temperature. Early detection and treatment of patients at risk is important in both clinical and economic concerns related to AKI.

中文翻译：

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温度是急诊就诊急性肾损伤的危险因素：韩国首尔的病例交叉研究

先前的研究表明，环境温度的升高是急性肾损伤（AKI）的危险因素之一。但是，在我们位于韩国首尔的所在地，尚未对其进行充分的研究。在这项研究中，我们旨在使用急诊科（ED）的就诊数据检查环境温度与AKI发病率之间的关系。我们从国家急诊中心获得了2010年至2014年报告的21,656例AKI急诊就诊数据。基于条件逻辑回归的时间分层病例交叉设计分析用于分析环境温度对术后AKI的短期影响控制相关的协变量。研究了暴露-反应曲线的形状，个体人口特征，季节和合并症的影响修正以及滞后效应。滞后0时，每升高1°C，比值比（OR）为1.0087（95％置信区间[CI]：1.0041–1.0134）。温暖季节的风险更高（OR = 1.0149； 95％CI：1.0065–1.0234），高于寒冷季节（OR = 1.0059； 95％CI：1.0003–1.0116），甚至高于22.3°C（OR = 1.0235； 95％CI：1.0003–1.0116）。 95％CI：1.0230–1.0239）。这项研究提供了证据，表明AKI的ED访视与环境温度有关。在与AKI相关的临床和经济方面，对有风险的患者进行早期发现和治疗都很重要。这项研究提供了证据，表明AKI的ED访视与环境温度有关。在与AKI相关的临床和经济方面，对有风险的患者进行早期发现和治疗都很重要。这项研究提供了证据，表明AKI的ED访视与环境温度有关。在与AKI相关的临床和经济方面，对有风险的患者进行早期发现和治疗都很重要。