Functional neuroimaging studies suggest that prefrontal cortex dysfunction is present in people with autism spectrum disorder (ASD). Near-infrared spectroscopy is a noninvasive optical tool for examining oxygenation and hemodynamic changes in the cerebral cortex by measuring changes in oxygenated hemoglobin. Twelve drug-naïve male participants, aged 7–15 years and diagnosed with ASD according to DSM-5 criteria, and 12 age- and intelligence quotient (IQ)-matched healthy control males participated in the present study after giving informed consent. Relative concentrations of oxyhemoglobin were measured with frontal probes every 0.1 s during the Stroop color-word task, using 24-channel near-infrared spectroscopy. Oxyhemoglobin changes during the Stroop color-word task in the ASD group were significantly smaller than those in the control group at channels 12 and 13, located over the dorsolateral prefrontal cortex (FDR-corrected P: 0.0021–0.0063). The results suggest that male children with ASD have reduced prefrontal hemodynamic responses, measured with near-infrared spectroscopy.

中文翻译：

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用近红外光谱测量小儿自闭症谱系障碍的前额叶血流动力学反应降低

功能性神经影像学研究表明，自闭症谱系障碍 (ASD) 患者存在前额叶皮质功能障碍。近红外光谱是一种无创光学工具，通过测量氧合血红蛋白的变化来检查大脑皮层的氧合和血流动力学变化。12 名 7-15 岁且根据 DSM-5 标准诊断为 ASD 的未用药男性参与者和 12 名年龄和智商 (IQ) 匹配的健康对照男性在知情同意后参与了本研究。在 Stroop 颜色词任务期间，使用 24 通道近红外光谱每 0.1 秒用额叶探针测量氧合血红蛋白的相对浓度。ASD 组 Stroop 颜色词任务期间的氧合血红蛋白变化显着小于对照组，位于背外侧前额叶皮层上方的通道 12 和 13（FDR 校正 P：0.0021-0.0063）。结果表明，通过近红外光谱测量，患有 ASD 的男性前额叶血流动力学反应降低。