Ventricular Zone Expressed PH Domain-Containing 1 (VEPH1) is an 833-amino acid protein encoded by an evolutionarily conserved single-copy gene that emerged with pseudocoelomates. This gene has no paralog in any species identified to date and few studies have investigated the function of its encoded protein. Loss of expression of its ortholog, melted, in Drosophila results in a severe neural phenotype and impacts TOR, FoxO, and Hippo signaling. Studies in mammals indicate a role for VEPH1 in modulating TGFβ signaling and AKT activation, while numerous studies indicate VEPH1 expression is altered in several pathological conditions, including cancer. Although often referred to as an uncharacterized protein, available evidence supports VEPH1 as an adaptor protein capable of modulating multiple signal transduction networks. Further studies are required to define these adaptor functions and the role of VEPH1 in development and disease progression.

中文翻译：

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心室区表达的PH域包含1（VEPH1）：一种衔接蛋白，能够在正常和病理发展过程中调节多个信号转导途径。

心室区表达的PH包含域1（VEPH1）是一种833个氨基酸的蛋白质，由与拟腔皮动物一起出现的进化保守的单拷贝基因编码。迄今为止，该基因在任何物种中都没有旁系同源物，很少有研究调查其编码蛋白的功能。在果蝇中其直系同源物表达的丧失融化，导致严重的神经表型，并影响TOR，FoxO和Hippo信号传导。哺乳动物的研究表明VEPH1在调节TGFβ信号传导和AKT激活中的作用，而大量研究表明VEPH1的表达在包括癌症在内的几种病理状况下均发生了改变。尽管通常被称为未表征的蛋白，但现有证据支持VEPH1作为能够调节多种信号转导网络的衔接蛋白。