BACKGROUND The aim of the present study is to examine the effects of free fatty acids (FFAs) on major cardiovascular events (MACEs) in patients with stable coronary artery disease (CAD) and different glucose metabolism status. METHODS In this study, we consecutively enrolled 5443 patients from March 2011 to May 2015. Patients were categorized according to both status of glucose metabolism status [diabetes mellitus (DM), pre-diabetes (Pre-DM), normal glycaemia regulation (NGR)] and FFAs levels. All subjects were followed up for the occurrence of the MACEs. RESULTS During a median of 6.7 years' follow-up, 608 MACEs occurred. A twofold higher FFAs level was independently associated with MACEs after adjusting for confounding factors [Hazard Ratio (HR): 1.242, 95% confidence interval (CI) 1.084-1.424, p value = 0.002]. Adding FFAs to the Cox model increased the C-statistic by 0.015 (0.005-0.027). No significant difference in MACEs was observed between NGR and Pre-DM groups (p > 0.05). When patients were categorized by both status of glucose metabolism and FFAs levels, medium and high FFAs were associated with significantly higher risk of MACEs in Pre-DM [1.736 (1.018-2.959) and 1.779 (1.012-3.126), all p-value < 0.05] and DM [2.017 (1.164-3.494) and 2.795 (1.619-4.824), all p-value < 0.05]. CONCLUSIONS The present data indicated that baseline FFAs levels were associated with the prognosis in DM and Pre-DM patients with CAD, suggesting that FFAs may be a valuable predictor in patients with impaired glucose metabolism.

中文翻译：

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游离脂肪酸对不同糖代谢状态下冠心病患者预后的影响

背景技术本研究的目的是研究游离脂肪酸（FFA）对稳定冠状动脉疾病（CAD）和不同葡萄糖代谢状态患者的主要心血管事件（MACE）的影响。方法在本研究中，我们从2011年3月至2015年5月连续招募5443例患者。根据糖代谢状态[糖尿病（DM），糖尿病前（DM），正常血糖调节（NGR）]对患者进行分类。 ]和FFA级别。对所有受试者进行了MACE的随访。结果在平均6.7年的随访中，发生了608例MACE。调整混杂因素后，FFE水平升高两倍，与MACE独立相关[危险比（HR）：1.242，95％置信区间（CI）1.084-1.424，p值= 0.002]。将FFA添加到Cox模型中可使C统计量增加0.015（0.005-0.027）。NGR组和Pre-DM组之间未观察到MACE的显着差异（p> 0.05）。当按糖代谢状态和FFAs水平对患者进行分类时，中，高FFAs与Pre-DM前发生MACE的风险显着相关[1.736（1.018-2.959）和1.779（1.012-3.126），所有p值< 0.05]和DM [2.017（1.164-3.494）和2.795（1.619-4.824），所有p值<0.05]。结论目前的数据表明，基线FFA水平与DM和Pre-DM合并CAD的患者的预后相关，这表明FFA可能是糖代谢受损患者的重要预测指标。0.05）。如果按糖代谢状态和FFAs水平对患者进行分类，则中，高FFAs与Pre-DM前发生MACE的风险显着较高[1.736（1.018-2.959）和1.779（1.012-3.126），所有p值< 0.05]和DM [2.017（1.164-3.494）和2.795（1.619-4.824），所有p值<0.05]。结论目前的数据表明，基线FFA水平与DM和Pre-DM合并CAD的患者的预后相关，这表明FFA可能是糖代谢受损患者的重要预测指标。0.05）。如果按糖代谢状态和FFAs水平对患者进行分类，则中，高FFAs与Pre-DM前发生MACE的风险显着较高[1.736（1.018-2.959）和1.779（1.012-3.126），所有p值< 0.05]和DM [2.017（1.164-3.494）和2.795（1.619-4.824），所有p值<0.05]。结论目前的数据表明，基线FFA水平与DM和Pre-DM合并CAD的患者的预后相关，这表明FFA可能是糖代谢受损患者的重要预测指标。所有p值<0.05]。结论目前的数据表明，基线FFA水平与DM和Pre-DM合并CAD的患者的预后相关，这表明FFA可能是糖代谢受损患者的重要预测指标。所有p值<0.05]。结论目前的数据表明，基线FFA水平与DM和Pre-DM合并CAD的患者的预后相关，这表明FFA可能是糖代谢受损患者的重要预测指标。