BACKGROUND Visceral fat area (VFA) is a good surrogate marker of obesity-related disorders, such as hypertension, dyslipidemia and glucose intolerance. Although estimating the VFA by X-ray computed tomography (CT) is the primary index for visceral obesity, it is expensive and requires invasive radiation exposure. Dual bioelectrical impedance analysis (BIA) is a simple and reliable method to estimate VFA; however, the clinical usefulness of dual BIA remains unclear in patients with type 2 diabetes (T2D). METHODS We estimated the VFAs by dual BIA and CT in 98 patients with T2D and assessed anthropometric parameters, blood test results, and the presence of comorbid hypertension and dyslipidemia. We compared the correlation between the VFAs examined by dual BIA and CT. Furthermore, we performed the receiver operating characteristic (ROC) analyses for the VFAs to detect the presence of comorbid hypertension and/or dyslipidemia with T2D, which are major comorbidities of visceral obesity, and estimated the area under the curve (AUC). RESULTS The measurement error between the VFAs by dual BIA and CT was significantly higher among patients with brain natriuretic peptide (BNP) ≥ 100 pg/mL than those with BNP < 100 pg/mL (39.2% ± 31.1% vs. 24.1% ± 18.6%, P < 0.05). After excluding patients with BNP ≥ 100 pg/mL, the VFA by dual BIA significantly correlated with the VFA by CT (r = 0.917; P < 0.0001). The AUC in the ROC analysis for the VFA by dual BIA to detect the presence of comorbid hypertension and/or dyslipidemia with T2D was almost equivalent to that for the VFA by CT. CONCLUSIONS In patients with T2D without elevated BNP > 100 pg/mL as indicator for fluid accumulation interfering with BIA, estimation of the VFA by dual BIA significantly correlated with that by CT and also detected comorbid hypertension and/or dyslipidemia with T2D equivalent to those detected by CT. Hence, dual BIA could be an alternative to CT as a standard method for estimating the VFA in patients with diabetes.

中文翻译：

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通过双重生物电阻抗分析估算内脏脂肪在检测2型糖尿病患者心血管危险因素中的功效。

背景技术内脏脂肪区（VFA）是肥胖相关疾病（例如高血压，血脂异常和葡萄糖不耐症）的良好替代指标。尽管通过X射线计算机断层扫描（CT）估算VFA是内脏型肥胖的主要指标，但它昂贵且需要侵入性辐射暴露。双重生物电阻抗分析（BIA）是一种简单而可靠的估算VFA的方法。然而，双重BIA在2型糖尿病（T2D）患者中的临床用途仍不清楚。方法我们通过BIA和CT双重BIA和CT评估了98位T2D患者的VFA，并评估了人体测量学参数，血液检查结果以及合并症高血压和血脂异常。我们比较了双BIA和CT检查的VFA之间的相关性。此外，我们对VFA进行了接​​收器操作特征（ROC）分析，以检测合并有T2D的高血压和/或血脂异常，这是内脏肥胖的主要合并症，并估算曲线下面积（AUC）。结果在脑钠肽（BNP）≥100 pg / mL的患者中，双BIA和CT的VFA测量误差明显高于BNP <100 pg / mL的患者（39.2％±31.1％vs. 24.1％±18.6 ％，P ＜0.05）。在排除BNP≥100 pg / mL的患者后，双重BIA的VFA与CT的VFA显着相关（r = 0.917； P <0.0001）。通过双BIA对VFA进行ROC分析以检测是否存在合并T2D的合并高血压和/或血脂异常的AUC与CT对VFA的AUC几乎相等。结论在没有升高的BNP> 100 pg / mL的T2D患者作为BIA干扰液体积聚的指标时，双重BIA对VFA的评估与CT显着相关，并且与T2D等同检测到合并性高血压和/或血脂异常通过CT。因此，双重BIA可以替代CT作为评估糖尿病患者VFA的标准方法。