Metabolic syndrome (MetS) and serum prostate-specific antigen (PSA) levels are correlated. To investigate the underlying effect of MetS on PSA levels, the relationship between the major pathogenic factors of MetS and serum PSA levels was studied. A total of 506 ostensibly healthy men who underwent routine health check-ups were recruited to this study. We evaluated the effect of the major pathogenic factors of MetS, which included insulin resistance, a subclinical inflammatory state and sexual hormone changes, on serum PSA levels by using linear regression analysis and multivariate analysis after adjusting for age, BMI and prostate volume. When simultaneously adjusting for age, BMI, prostate volume and high-density lipoprotein cholesterol, serum insulin levels and SHBG levels were inversely correlated with serum PSA levels (P = 0.049 and P = 0.004, respectively), and testosterone levels were positively correlated with serum PSA levels (P = 0.039). In multivariate regression models, serum insulin levels and serum SHBG levels were significantly associated with serum PSA levels (both P < 0.001). Among the major pathogenic factors of metabolic syndrome, insulin resistance and sexual hormone changes may be the most significant contributors to the decline in serum PSA levels.

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代谢综合征的致病因素与血清前列腺特异性抗原水平的关系：一项初步研究

代谢综合征（MetS）与血清前列腺特异性抗原（PSA）水平相关。为了研究MetS对PSA水平的潜在影响，研究了MetS的主要致病因素与血清PSA水平之间的关系。总共506名表面健康的男性接受了常规的健康检查。我们在调整了年龄，BMI和前列腺体积后，通过线性回归分析和多元分析，评估了MetS的主要致病因素，包括胰岛素抵抗，亚临床炎症状态和性激素变化，对血清PSA水平的影响。同时调整年龄，BMI，前列腺体积和高密度脂蛋白胆固醇，血清胰岛素水平和SHBG水平与血清​​PSA水平呈负相关（P = 0.049和P = 0.004，），而睾丸激素水平与血清​​PSA水平呈正相关（P = 0.039）。在多元回归模型中，血清胰岛素水平和血清SHBG水平与血清​​PSA水平显着相关（均P <0.001）。在代谢综合征的主要致病因素中，胰岛素抵抗和性激素变化可能是导致血清PSA水平下降的最主要因素。