Previous studies of prognosis for women with Fibromyalgia (FM) or chronic widespread pain (CWP) show contradictory results. However, some women appear to improve in pain and other core symptoms over time. There is limited knowledge about predictors of substantial improvement in pain intensity over a longer period of time. The primary objective of this study was to investigate the natural course of pain intensity and distribution of pain over 10 to 12 years in a cohort of 166 women with FM or CWP. Secondarily we wanted to investigate predictors of substantial improvement (≥50%) in pain intensity after 10 to 12 years. The study is a longitudinal prospective cohort study. 166 women with FM or CWP were followed up after 10 to 12 years. 126 women (76%) participated in the follow-up and completed a battery of questionnaires concerning pain intensity, pain distribution and other physical and mental aspects of health. Differences in symptoms within the cohort over 10 to 12 years and predictors of substantial improvement (≥50%) in pain intensity were calculated. Pain had improved at the 10 to 12 year follow-up (p < 0.001) with a mean change of − 9.2 mm (SD 23.3, 95% CI: − 13.3; − 5.0) for pain intensity and − 2.0 sites (SD 4.2, 95% CI: − 2.7; − 1.2) for pain distribution. Nine percent of the 126 women showed an individual moderate improvement in pain intensity while 16% showed a substantial improvement at the follow-up as compared to baseline. Lower symptoms of stress and higher pain intensity at baseline predicted higher probability of reporting at least 50% less pain intensity after 10 to 12 years as compared to baseline. A majority of women with FM and CWP appear to have a positive course of pain over time, which should be communicated to these patients in health care. Reducing stress levels might contribute to better chances of improvement over time. Clinicaltrials.gov NCT02872129 , registered 06/30/2016.

中文翻译：

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压力水平预测患有纤维肌痛和慢性广泛性疼痛的女性在 10 至 12 年后疼痛强度会显着改善：一项队列研究

先前对患有纤维肌痛 (FM) 或慢性广泛性疼痛 (CWP) 的女性的预后研究显示出相互矛盾的结果。然而，随着时间的推移，一些女性的疼痛和其他核心症状似乎有所改善。关于疼痛强度在较长时间内显着改善的预测因素的知识有限。本研究的主要目的是在 166 名 FM 或 CWP 女性的队列中调查 10 至 12 年间疼痛强度和疼痛分布的自然过程。其次，我们想研究 10 至 12 年后疼痛强度显着改善（≥50%）的预测因素。该研究是一项纵向前瞻性队列研究。166 名患有 FM 或 CWP 的女性在 10 至 12 年后进行了随访。126 名女性 (76%) 参与了随访并完成了一系列关于疼痛强度的问卷，疼痛分布和其他身心健康方面。计算了 10 至 12 年队列内症状的差异以及疼痛强度显着改善（≥50%）的预测因子。在 10 至 12 年的随访中疼痛有所改善 (p < 0.001)，疼痛强度的平均变化为 - 9.2 mm (SD 23.3, 95% CI: - 13.3; - 5.0) 和 - 2.0 个部位 (SD 4.2, 95% CI：- 2.7；- 1.2) 疼痛分布。与基线相比，126 名女性中有 9% 的个体疼痛强度有所改善，而 16% 的女性在随访中表现出显着改善。与基线相比，基线时较低的压力症状和较高的疼痛强度预示着在 10 至 12 年后报告疼痛强度至少降低 50% 的可能性更高。随着时间的推移，大多数患有 FM 和 CWP 的女性似乎会出现积极的疼痛过程，这应该在医疗保健中传达给这些患者。随着时间的推移，降低压力水平可能有助于提高改善的机会。Clinicaltrials.gov NCT02872129，2016 年 6 月 30 日注册。