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Use of long acting injectable aripiprazole before and through pregnancy in bipolar disorder: a case report.
BMC Pharmacology and Toxicology ( IF 2.8 ) Pub Date : 2019-08-28 , DOI: 10.1186/s40360-019-0330-x
Isabel Ballester-Gracia 1 , Miriam Pérez-Almarcha 1 , Ana Galvez-Llompart 1 , Miguel Hernandez-Viadel 1, 2, 3
Affiliation  

BACKGROUND Long-acting injectable (LAI) antipsychotics for psychotic disorders provide advantages in treatment compliance, but data on their use in pregnancy are very limited. We present a clinical case of aripiprazole LAI use in pregnancy. CASE PRESENTATION A 43-year-old woman diagnosed with bipolar disorder, with several relapses due to treatment interruption while trying to conceive. Finally, aripiprazole LAI treatment was planned by mutual agreement between doctor and the patient, who took aripiprazole LAI before and during pregnancy. She gave birth at 40 weeks to a 3500 g baby girl with no congenital malformations, who was healthy at 5 months after delivery. CONCLUSION As far as we know, this is the first case report on aripiprazole LAI use during pregnancy. Although we exercise caution in drawing conclusions from a single case, and each case should be weighed up individually, aripiprazole LAI could be a therapeutic option in similar circumstances.

中文翻译:

双相情感障碍孕妇在妊娠前和妊娠期间使用长效可注射阿立哌唑:一例病例报告。

背景技术用于精神病性疾病的长效注射(LAI)抗精神病药在治疗依从性方面具有优势,但有关其在妊娠中使用的数据非常有限。我们目前在孕妇中使用阿立哌唑LAI的临床案例。病例介绍一名43岁的女性被诊断出患有躁郁症,由于试图怀孕时治疗中断而复发。最后,通过医生和患者之间的相互协议,计划了阿立哌唑LAI的治疗,该患者在怀孕之前和怀孕期间服用了阿立哌唑LAI。她在第40周出生了3500 g无先天性畸形的女婴,该女婴在分娩后5个月就健康了。结论据我们所知,这是关于怀孕期间使用阿立哌唑LAI的第一例病例报告。尽管我们在从单个案例中得出结论时要谨慎行事,
更新日期:2019-08-28
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