BACKGROUND The investigation of food-drug and plant-drug interactions has become increasingly important. In case of antibiotics, it is essential to achieve and maintain a plasma concentration sufficient for the antimicrobial action. Although, on theoretical basis, the interaction of polyphenols and antibiotics may be hypothesized, experimental data are lacking to assess its clinical relevance. The aim of our study was to assess the interaction between one of the most widely used antibiotics, amoxicillin, and green tea, the most frequently consumed drink with high polyphenol content. METHODS The effects of green tea on the plasma level of amoxicillin was studied in an in vivo experiment in rats. The plasma level of amoxicillin was monitored by LC-MS/MS for 240 min after oral administration. The polyphenol content of green tea was determined by the Folin-Ciocalteu method. RESULTS The peak plasma concentration of amoxicillin significantly decreased upon its co-administration with green tea, although the AUC0-240 of the antibiotic did not decrease significantly in the group treated with amoxicillin suspended in green tea. CONCLUSIONS Our results suggest a potentially relevant interaction between green tea and amoxicillin, worth being further studied in humans.

中文翻译：

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绿茶对大鼠阿莫西林胃肠吸收的影响。

背景技术食物-药物和植物-药物相互作用的研究变得越来越重要。对于抗生素，必须达到并维持足以发挥抗菌作用的血浆浓度。尽管在理论基础上可以假设多酚和抗生素之间存在相互作用，但缺乏实验数据来评估其临床相关性。我们研究的目的是评估最广泛使用的抗生素之一阿莫西林和绿茶（最常饮用的多酚含量高的饮料）之间的相互作用。方法通过大鼠体内实验研究绿茶对阿莫西林血浆水平的影响。口服给药后240分钟通过LC-MS/MS监测阿莫西林的血浆水平。采用 Folin-Ciocalteu 法测定绿茶多酚含量。结果阿莫西林与绿茶合用后，血浆峰浓度显着降低，但阿莫西林绿茶悬浮液治疗组中抗生素的 AUC0-240 并未显着降低。结论我们的结果表明绿茶和阿莫西林之间存在潜在的相关相互作用，值得在人类中进一步研究。