BackgroundTranscranial focused ultrasound (tFUS) attracts wide attention in neuroscience as an effective noninvasive approach to modulate brain circuits. In spite of this, the effects of tFUS on the brain is still unclear, and further investigation is needed. The present study proposes to use near-infrared spectroscopy (NIRS) to observe cerebral hemodynamic change caused by tFUS in a noninvasive manner.ResultsThe results show a transient increase of oxyhemoglobin and decrease of deoxyhemoglobin concentration in the mouse model induced by ultrasound stimulation of the somatosensory cortex with a frequency of 8 MHz but not in sham. In addition, the amplitude of hemodynamics change can be related to the peak intensity of the acoustic wave.ConclusionHigh frequency 8 MHz ultrasound was shown to induce hemodynamic changes measured using NIRS through the intact mouse head. The implementation of NIRS offers the possibility of investigating brain response noninvasively for different tFUS parameters through cerebral hemodynamic change.

中文翻译：

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使用近红外光谱仪无创测量 8 MHz 经颅聚焦超声刺激期间的血流动力学变化

背景经颅聚焦超声（tFUS）作为一种有效的非侵入性调节大脑回路的方法引起了神经科学的广泛关注。尽管如此，tFUS 对大脑的影响仍不清楚，需要进一步研究。本研究提出利用近红外光谱（NIRS）以无创的方式观察tFUS引起的脑血流动力学变化。结果结果显示，超声刺激体感小鼠模型中，氧合血红蛋白浓度短暂升高，脱氧血红蛋白浓度降低。皮层频率为 8 MHz，但假手术中没有。此外，血流动力学变化的幅度可能与声波的峰值强度有关。 结论高频 8 MHz 超声显示可诱导使用 NIRS 通过完整小鼠头部测量的血流动力学变化。NIRS 的实施提供了通过脑血流动力学变化无创研究不同 tFUS 参数的大脑反应的可能性。