BACKGROUND The use of systematic review methods are widely recognized to be essential in the development of recommendations in clinical practice guidelines to prove their trustworthiness. The objective of this study was to assess the use of systematic search methods by authors of guidelines published in the oncology field. METHODS We analyzed 590 guidance documents identified in PubMed, NGC, GIN and web sites for guidelines in 2009-2015 in oncology. The main outcome measure used was incidence of guidance documents supported by a systematic search of the literature. In addition to descriptive analyses, logistic regression was used to evaluate if adequate search methods were explained by guideline characteristics. RESULTS Of 590 guidance documents included in the study, 305 (51.7%) declared the use of systematic search methods but only 168 (28.5%) applied methods meeting minimum standards for quality and provided sufficient details to allow classification. 164 (27.8%) guidance documents did not report any use of literature evaluation. Guidance documents produced by a Government Agency in North America (OR 2.16, 95% CI 1.16-4.17) and those with a focused scope (OR 2.35, 95% CI 0.97-5.56) were positively associated with the use of systematic search methods. We found no association between the year of publication and use of systematic search methods. CONCLUSIONS A relatively small number of guidance documents was informed by scientific evidence identified through adequate systematic search methods. We observed substantial room for improvement of applied methods and reporting, especially in documents with a broad focus, or those produced by professional societies or independent expert panels in other continents than North America.

中文翻译：

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肿瘤临床实践指南中对系统搜索方法的吸收不足：系统综述。

背景技术在临床实践指南中，为了证明其可信度，在开发推荐建议时，广泛使用系统评价方法是必不可少的。这项研究的目的是评估在肿瘤学领域发表的指南作者对系统搜索方法的使用。方法我们分析了PubMed，NGC，GIN和网站中确定的590篇指导文件，作为2009-2015年肿瘤学指南。所使用的主要结果指标是通过系统搜索文献的指导文件的发生率。除了描述性分析之外，逻辑回归还用于评估指南特征是否解释了适当的搜索方法。结果在研究中包括的590份指导文件中，有305（51.7％）宣布使用系统搜索方法，但只有168（28。5％）的应用方法要达到最低质量标准，并提供足够的详细信息以进行分类。164（27.8％）份指导文件没有报告对文献评估的任何使用。北美政府机构（OR 2.16，95％CI 1.16-4.17）和重点范围文件（OR 2.35，95％CI 0.97-5.56）产生的指导文件与系统搜索方法的使用正相关。我们发现出版年份与系统搜索方法的使用之间没有关联。结论相对较少的指导文件是通过适当的系统检索方法鉴定的科学证据提供的。我们发现应用方法和报告有很大的改进空间，尤其是在广泛关注的文档中，